Comparison of Oxidative Stress Parameters in Heart Failure Patients Depending on Ischaemic or Nonischaemic Aetiology

Background. Abnormalities in the oxidative and antioxidant states causing oxidative stress were both found in heart failure (HF) of various aetiologies and atherosclerosis. Aim of Study. The goals of the study were as follows: comparison of oxidative stress parameters (OSP) in ischaemic cardiomyopat...

Full description

Saved in:
Bibliographic Details
Published in:Oxidative medicine and cellular longevity 2019, Vol.2019 (2019), p.1-13
Main Authors: Rozentryt, Piotr, Birkner, Ewa, Malinowska-Borowska, Jolanta, Niedziela, Jacek, Nowak, Jolanta, Jacheć, Wojciech, Wojciechowska, Celina, Romuk, Ewa, Głogowska-Gruszka, Anna
Format: Article
Language:English
Subjects:
Adult
Albumin
Analysis
Antioxidants
Antioxidants - metabolism
Atherosclerosis
Beta blockers
Bilirubin
Biomarkers
Cardiac patients
Ejection fraction
Heart failure
Heart Failure - genetics
Humans
Metabolism
Middle Aged
Mortality
Oxidants - blood
Oxidation
Oxidative stress
Oxidative Stress - genetics
Prospective Studies
Uric acid
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background. Abnormalities in the oxidative and antioxidant states causing oxidative stress were both found in heart failure (HF) of various aetiologies and atherosclerosis. Aim of Study. The goals of the study were as follows: comparison of oxidative stress parameters (OSP) in ischaemic cardiomyopathy (ICM) (n=479) and nonischaemic cardiomyopathy (nICM) (n=295) patients; assessment of the relationships of OSP with functional capacity (NYHA class), maximal oxygen consumption (max.O2), left ventricle ejection fraction (LVEF), and NT-proBNP concentration; and determination of the mutual relations of OSP in subgroups of patients with ICM and n-ICM. Methods. Serum concentrations of total antioxidant capacity (TAC), total oxidant status (TOS), uric acid (UA), bilirubin, albumin, protein sulfhydryl groups (PSH), and malondialdehyde (MDA) were measured. The oxidative stress index (OSI) and MDA/PSH ratio were calculated. Results. Higher concentrations of TAC (1.14 vs 1.11 mmol/l; p
ISSN:1942-0900
1942-0994
DOI:10.1155/2019/7156038