EpCAMlow Circulating Tumor Cells: Gold in the Waste

The CellSearch® system which is still considered the gold standard for the enumeration of circulating tumor cells (CTC) utilizes antibodies against the epithelial cell adhesion molecule (EpCAM) for CTC enrichment. Recently, CTC discarded by the CellSearch® system due to their low EpCAM expression ha...

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Bibliographic Details
Published in:Disease markers 2019-01, Vol.2019 (2019), p.1-5
Main Authors: Raimondi, Cristina, Loreni, Flavia, Gradilone, Angela, Nicolazzo, Chiara, Gazzaniga, Paola
Format: Article
Language:English
Subjects:
Antibodies
Antigens
Breast cancer
Cell adhesion
Cell adhesion & migration
Cell adhesion molecules
Enumeration
Epithelial cells
Immunoglobulins
Lung cancer
Medical prognosis
Medical research
Metastasis
Oncology
Patients
Prostate
Review
Studies
Tumor cells
Tumors
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Summary:The CellSearch® system which is still considered the gold standard for the enumeration of circulating tumor cells (CTC) utilizes antibodies against the epithelial cell adhesion molecule (EpCAM) for CTC enrichment. Recently, CTC discarded by the CellSearch® system due to their low EpCAM expression have been isolated and analyzed. We here sought to discuss technical and biological issues concerning the isolation and characterization of EpCAMlow CTC, highlighting the enormous potential of this subpopulation discarded by CellSearch®, which might instead reveal an unexpected clinical significance in tumor types where CTC enumeration has never been validated for prognostic and predictive purpose.
ISSN:0278-0240
1875-8630
DOI:10.1155/2019/1718920