Renal dysfunction by baseline CD4 cell count in a cohort of adults starting antiretroviral treatment regardless of CD4 count in the HIV Prevention Trials Network 071 [HPTN 071; Population Effect of Antiretroviral Therapy to Reduce HIV Transmission (PopART)] study in South Africa

Objectives Renal dysfunction is a significant cause of morbidity and mortality among HIV‐positive individuals. This study evaluated renal dysfunction in a cohort of adults who started antiretroviral treatment (ART) regardless of CD4 count at three Department of Health (DOH) clinics included in the H...

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Bibliographic Details
Published in:HIV medicine 2019-07, Vol.20 (6), p.392-403
Main Authors: Bock, P, Nel, K, Fatti, G, Sloot, R, Ford, N, Voget, J, Gunst, C, Grobbelaar, N, Louis, F, Floyd, S, Hayes, R, Ayles, H, Beyers, N, Fidler, S
Format: Article
Language:English
Subjects:
Adolescent
Adult
Adults
Aged
Aged, 80 and over
Anti-Retroviral Agents - therapeutic use
Antiretroviral agents
Antiretroviral therapy
antiretroviral treatment
CD4 antigen
CD4 count
CD4 Lymphocyte Count
Confidence intervals
Disease prevention
Disease transmission
Epidermal growth factor receptors
Female
Glomerular Filtration Rate
HIV
HIV Infections - complications
HIV Infections - drug therapy
HIV Infections - pathology
HIV Infections - prevention & control
HIV/AIDS
Human immunodeficiency virus
Humans
Kidney Diseases - epidemiology
Male
Middle Aged
Morbidity
Original Research
Prevention
Regression analysis
renal dysfunction
Renal function
Retrospective Studies
South Africa
Statistical analysis
Surveys and Questionnaires
Tenofovir
Young Adult
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Summary:Objectives Renal dysfunction is a significant cause of morbidity and mortality among HIV‐positive individuals. This study evaluated renal dysfunction in a cohort of adults who started antiretroviral treatment (ART) regardless of CD4 count at three Department of Health (DOH) clinics included in the HIV Prevention Trials Network 071 (HPTN 071) Population Effect of Antiretroviral Therapy to Reduce HIV Transmission (PopART) trial. Methods A retrospective cohort analysis of routine data for HIV‐positive individuals starting ART between January 2014 and November 2015 was completed. Incident renal dysfunction was defined as an estimated glomerular filtration rate (eEGFR)
ISSN:1464-2662
1468-1293
DOI:10.1111/hiv.12729