The role of endothelial glycocalyx in health and disease

Abstract The endothelium is the largest organ in the body and recent studies have shown that the endothelial glycocalyx (eGCX) plays a major role in health and disease states. The integrity of eGCX is vital for homoeostasis and disruption of its structure and function plays a major role in several p...

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Bibliographic Details
Published in:Clinical kidney journal 2019-10, Vol.12 (5), p.611-619
Main Authors: Yilmaz, Onur, Afsar, Baris, Ortiz, Alberto, Kanbay, Mehmet
Format: Article
Language:English
Subjects:
Chronic kidney failure
Diabetes mellitus
Diseases
Endothelium
Glycocalyx
Health
Health aspects
Hyaluronidase
Kidney diseases
Novels
Pathophysiology
Physiological aspects
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Summary:Abstract The endothelium is the largest organ in the body and recent studies have shown that the endothelial glycocalyx (eGCX) plays a major role in health and disease states. The integrity of eGCX is vital for homoeostasis and disruption of its structure and function plays a major role in several pathologic conditions. An increased understanding of the numerous pathophysiological roles of eGCX may lead to the development of potential surrogate markers for endothelial injury or novel therapeutic targets. This review provides a state-of-the-art update on the structure and function of the eGCX, emphasizing the current understanding of interorgan crosstalk between the eGCX and other organs that might also contribute to the pathogenesis of kidney diseases.
ISSN:2048-8505
2048-8513
DOI:10.1093/ckj/sfz042