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The role of endothelial glycocalyx in health and disease
Abstract The endothelium is the largest organ in the body and recent studies have shown that the endothelial glycocalyx (eGCX) plays a major role in health and disease states. The integrity of eGCX is vital for homoeostasis and disruption of its structure and function plays a major role in several p...
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| Published in: | Clinical kidney journal 2019-10, Vol.12 (5), p.611-619 |
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| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c518t-36a1045f63a66383c840d4f2ffcb5645c736a36b4f7d79af87c55f27667224343 |
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| cites | cdi_FETCH-LOGICAL-c518t-36a1045f63a66383c840d4f2ffcb5645c736a36b4f7d79af87c55f27667224343 |
| container_end_page | 619 |
| container_issue | 5 |
| container_start_page | 611 |
| container_title | Clinical kidney journal |
| container_volume | 12 |
| creator | Yilmaz, Onur Afsar, Baris Ortiz, Alberto Kanbay, Mehmet |
| description | Abstract
The endothelium is the largest organ in the body and recent studies have shown that the endothelial glycocalyx (eGCX) plays a major role in health and disease states. The integrity of eGCX is vital for homoeostasis and disruption of its structure and function plays a major role in several pathologic conditions. An increased understanding of the numerous pathophysiological roles of eGCX may lead to the development of potential surrogate markers for endothelial injury or novel therapeutic targets. This review provides a state-of-the-art update on the structure and function of the eGCX, emphasizing the current understanding of interorgan crosstalk between the eGCX and other organs that might also contribute to the pathogenesis of kidney diseases. |
| doi_str_mv | 10.1093/ckj/sfz042 |
| format | article |
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The endothelium is the largest organ in the body and recent studies have shown that the endothelial glycocalyx (eGCX) plays a major role in health and disease states. The integrity of eGCX is vital for homoeostasis and disruption of its structure and function plays a major role in several pathologic conditions. An increased understanding of the numerous pathophysiological roles of eGCX may lead to the development of potential surrogate markers for endothelial injury or novel therapeutic targets. This review provides a state-of-the-art update on the structure and function of the eGCX, emphasizing the current understanding of interorgan crosstalk between the eGCX and other organs that might also contribute to the pathogenesis of kidney diseases.</description><identifier>ISSN: 2048-8505</identifier><identifier>EISSN: 2048-8513</identifier><identifier>DOI: 10.1093/ckj/sfz042</identifier><identifier>PMID: 31583086</identifier><language>eng</language><publisher>Oxford University Press</publisher><subject>Chronic kidney failure ; Diabetes mellitus ; Diseases ; Endothelium ; Glycocalyx ; Health ; Health aspects ; Hyaluronidase ; Kidney diseases ; Novels ; Pathophysiology ; Physiological aspects</subject><ispartof>Clinical kidney journal, 2019-10, Vol.12 (5), p.611-619</ispartof><rights>The Author(s) 2019. Published by Oxford University Press on behalf of ERA-EDTA. 2019</rights><rights>COPYRIGHT 2019 Oxford University Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c518t-36a1045f63a66383c840d4f2ffcb5645c736a36b4f7d79af87c55f27667224343</citedby><cites>FETCH-LOGICAL-c518t-36a1045f63a66383c840d4f2ffcb5645c736a36b4f7d79af87c55f27667224343</cites><orcidid>0000-0002-1297-0675</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6768294/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6768294/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,1598,27903,27904,53769,53771</link.rule.ids></links><search><creatorcontrib>Yilmaz, Onur</creatorcontrib><creatorcontrib>Afsar, Baris</creatorcontrib><creatorcontrib>Ortiz, Alberto</creatorcontrib><creatorcontrib>Kanbay, Mehmet</creatorcontrib><title>The role of endothelial glycocalyx in health and disease</title><title>Clinical kidney journal</title><description>Abstract
The endothelium is the largest organ in the body and recent studies have shown that the endothelial glycocalyx (eGCX) plays a major role in health and disease states. The integrity of eGCX is vital for homoeostasis and disruption of its structure and function plays a major role in several pathologic conditions. An increased understanding of the numerous pathophysiological roles of eGCX may lead to the development of potential surrogate markers for endothelial injury or novel therapeutic targets. This review provides a state-of-the-art update on the structure and function of the eGCX, emphasizing the current understanding of interorgan crosstalk between the eGCX and other organs that might also contribute to the pathogenesis of kidney diseases.</description><subject>Chronic kidney failure</subject><subject>Diabetes mellitus</subject><subject>Diseases</subject><subject>Endothelium</subject><subject>Glycocalyx</subject><subject>Health</subject><subject>Health aspects</subject><subject>Hyaluronidase</subject><subject>Kidney diseases</subject><subject>Novels</subject><subject>Pathophysiology</subject><subject>Physiological aspects</subject><issn>2048-8505</issn><issn>2048-8513</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>TOX</sourceid><recordid>eNp9kU1LAzEQhoMotlQv_oIFEURom83XphehFL-g4KWeQ5qddKPppm62Yv31pqwIBXFymCHzzDshL0IXOR7leELH5u11HO0XZuQI9Qlmcih5To9_a8x76DzGV5widTDjp6hHcy4plqKP5KKCrAkesmAzqMvQVuCd9tnK70ww2u8-M1dnFWjfVpmuy6x0EXSEM3RitY9w_pMH6OX-bjF7HM6fH55m0_nQ8Fy2Qyr0fqcVVAtBJTWS4ZJZYq1ZcsG4KRJBxZLZoiwm2srCcG5JIURBCKOMDtBtp7vZLtdQGqjbRnu1adxaNzsVtFOHndpVahU-lCiEJJO9wPWPQBPetxBbtXbRgPe6hrCNilCcM0Z5-rUBuuzQlfagXG1DUjR7XE1FTqUosCSJGv1BpVPC2plQg3Xp_mDgphswTYixAfv7-hyrvYkqmag6ExN81cFhu_mP-wahCpjp</recordid><startdate>20191001</startdate><enddate>20191001</enddate><creator>Yilmaz, Onur</creator><creator>Afsar, Baris</creator><creator>Ortiz, Alberto</creator><creator>Kanbay, Mehmet</creator><general>Oxford University Press</general><scope>TOX</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-1297-0675</orcidid></search><sort><creationdate>20191001</creationdate><title>The role of endothelial glycocalyx in health and disease</title><author>Yilmaz, Onur ; Afsar, Baris ; Ortiz, Alberto ; Kanbay, Mehmet</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c518t-36a1045f63a66383c840d4f2ffcb5645c736a36b4f7d79af87c55f27667224343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Chronic kidney failure</topic><topic>Diabetes mellitus</topic><topic>Diseases</topic><topic>Endothelium</topic><topic>Glycocalyx</topic><topic>Health</topic><topic>Health aspects</topic><topic>Hyaluronidase</topic><topic>Kidney diseases</topic><topic>Novels</topic><topic>Pathophysiology</topic><topic>Physiological aspects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yilmaz, Onur</creatorcontrib><creatorcontrib>Afsar, Baris</creatorcontrib><creatorcontrib>Ortiz, Alberto</creatorcontrib><creatorcontrib>Kanbay, Mehmet</creatorcontrib><collection>Oxford Academic Journals (Open Access)</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical kidney journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yilmaz, Onur</au><au>Afsar, Baris</au><au>Ortiz, Alberto</au><au>Kanbay, Mehmet</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of endothelial glycocalyx in health and disease</atitle><jtitle>Clinical kidney journal</jtitle><date>2019-10-01</date><risdate>2019</risdate><volume>12</volume><issue>5</issue><spage>611</spage><epage>619</epage><pages>611-619</pages><issn>2048-8505</issn><eissn>2048-8513</eissn><abstract>Abstract
The endothelium is the largest organ in the body and recent studies have shown that the endothelial glycocalyx (eGCX) plays a major role in health and disease states. The integrity of eGCX is vital for homoeostasis and disruption of its structure and function plays a major role in several pathologic conditions. An increased understanding of the numerous pathophysiological roles of eGCX may lead to the development of potential surrogate markers for endothelial injury or novel therapeutic targets. This review provides a state-of-the-art update on the structure and function of the eGCX, emphasizing the current understanding of interorgan crosstalk between the eGCX and other organs that might also contribute to the pathogenesis of kidney diseases.</abstract><pub>Oxford University Press</pub><pmid>31583086</pmid><doi>10.1093/ckj/sfz042</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-1297-0675</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2048-8505 |
| ispartof | Clinical kidney journal, 2019-10, Vol.12 (5), p.611-619 |
| issn | 2048-8505 2048-8513 |
| language | eng |
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| source | PubMed Central; Oxford Academic Journals (Open Access) |
| subjects | Chronic kidney failure Diabetes mellitus Diseases Endothelium Glycocalyx Health Health aspects Hyaluronidase Kidney diseases Novels Pathophysiology Physiological aspects |
| title | The role of endothelial glycocalyx in health and disease |
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