The Diverse Contributions of Fucose Linkages in Cancer

Fucosylation is a post-translational modification of glycans, proteins, and lipids that is responsible for many biological processes. Fucose conjugation via α(1,2), α(1,3), α(1,4), α(1,6), and O'- linkages to glycans, and variations in fucosylation linkages, has important implications for cance...

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Bibliographic Details
Published in:Cancers 2019-08, Vol.11 (9), p.1241
Main Authors: Keeley, Tyler S, Yang, Shengyu, Lau, Eric
Format: Article
Language:English
Subjects:
Antigens
Breast cancer
Cancer
Cancer therapies
Carbon
Cell surface
Chemotherapy
Chromatography
Endoplasmic reticulum
Fucose
Lipids
Mass spectrometry
Medical prognosis
Metabolism
Metastasis
Ovarian cancer
Patients
Polysaccharides
Post-translation
Prostate cancer
Proteins
Review
Scientific imaging
Signal transduction
T cell receptors
Tumorigenesis
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Summary:Fucosylation is a post-translational modification of glycans, proteins, and lipids that is responsible for many biological processes. Fucose conjugation via α(1,2), α(1,3), α(1,4), α(1,6), and O'- linkages to glycans, and variations in fucosylation linkages, has important implications for cancer biology. This review focuses on the roles that fucosylation plays in cancer, specifically through modulation of cell surface proteins and signaling pathways. How L-fucose and serum fucosylation patterns might be used for future clinical diagnostic, prognostic, and therapeutic approaches will be discussed.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers11091241