The expanded role of fatty acid metabolism in cancer: new aspects and targets

Abstract Cancer cells undergo metabolic reprogramming to support cell proliferation, growth, and dissemination. Alterations in lipid metabolism, and specifically the uptake and synthesis of fatty acids (FAs), comprise one well-documented aspect of this reprogramming. Recent studies have revealed an...

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Bibliographic Details
Published in:Precision clinical medicine 2019-09, Vol.2 (3), p.183-191
Main Authors: Chen, Ming, Huang, Jiaoti
Format: Article
Language:English
Subjects:
Review
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Summary:Abstract Cancer cells undergo metabolic reprogramming to support cell proliferation, growth, and dissemination. Alterations in lipid metabolism, and specifically the uptake and synthesis of fatty acids (FAs), comprise one well-documented aspect of this reprogramming. Recent studies have revealed an expanded range of roles played by FA in promoting the aggressiveness of cancer while simultaneously identifying new potential targets for cancer therapy. This article provides a brief review of these advances in our understanding of FA metabolism in cancer, highlighting both recent discoveries and the inherent challenges caused by the metabolic plasticity of cancer cells in targeting lipid metabolism for cancer therapy.
ISSN:2096-5303
2516-1571
DOI:10.1093/pcmedi/pbz017