Fluorescent Radiosensitizing Gold Nanoparticles

Ultrasmall polyaminocarboxylate-coated gold nanoparticles (NPs), Au@DTDTPA and Au@TADOTAGA, that have been recently developed exhibit a promising potential for image-guided radiotherapy. In order to render the radiosensitizing effect of these gold nanoparticles even more efficient, the study of thei...

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Bibliographic Details
Published in:International journal of molecular sciences 2019-09, Vol.20 (18), p.4618
Main Authors: Jiménez Sánchez, Gloria, Maury, Pauline, Stefancikova, Lenka, Campion, Océane, Laurent, Gautier, Chateau, Alicia, Bouraleh Hoch, Farhan, Boschetti, Frédéric, Denat, Franck, Pinel, Sophie, Devy, Jérôme, Porcel, Erika, Lacombe, Sandrine, Bazzi, Rana, Roux, Stéphane
Format: Article
Language:English
Subjects:
Accumulation
Acids
Animals
Bioengineering
Brain cancer
Carbocyanines - administration & dosage
Carbocyanines - analysis
Cell Line, Tumor
Computed tomography
Contrast agents
Female
Fluorescence
Fluorescence microscopy
Fluorescent Dyes - administration & dosage
Fluorescent Dyes - analysis
Gold
Gold - administration & dosage
Gold - analysis
Human health and pathology
Humans
Immobilization
In vivo methods and tests
Ionizing radiation
Life Sciences
Ligands
Magnetic resonance imaging
Medical imaging
Metal Nanoparticles - administration & dosage
Metal Nanoparticles - analysis
Metal Nanoparticles - ultrastructure
Mice
Mice, Inbred BALB C
Mice, Nude
Microscopy
Microscopy, Fluorescence - methods
Morphology
Nanoparticles
Neoplasms - diagnostic imaging
NMR
Nuclear magnetic resonance
Nuclear medicine
Optical Imaging - methods
Photon emission
Photons
Polyamines - analysis
Radiation therapy
Radiation-Sensitizing Agents - administration & dosage
Radiation-Sensitizing Agents - analysis
Radioactive tracers
Scintigraphy
Single photon emission computed tomography
Solid tumors
Technetium
Tomography
Tumors
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Summary:Ultrasmall polyaminocarboxylate-coated gold nanoparticles (NPs), Au@DTDTPA and Au@TADOTAGA, that have been recently developed exhibit a promising potential for image-guided radiotherapy. In order to render the radiosensitizing effect of these gold nanoparticles even more efficient, the study of their localization in cells is required to better understand the relation between the radiosensitizing properties of the agents and their localization in cells and in tumors. To achieve this goal, post-functionalization of Au@DTDTPA nanoparticles by near-infrared (NIF) organic dyes (aminated derivative of cyanine 5, Cy5-NH ) was performed. The immobilization of organic Cy5-NH dyes onto the gold nanoparticles confers to these radiosensitizers fluorescence properties which can be exploited for monitoring their internalization in cancerous cells, for determining their localization in cells by fluorescence microscopy (a common and powerful imaging tool in biology), and for following up on their accumulation in tumors after intravenous injection.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms20184618