Soluble HLA‐G levels in seminal plasma are associated with HLA‐G 3′UTR genotypes and haplotypes

Soluble HLA‐G (sHLA‐G) levels in human seminal plasma (SP) can be diverse and may affect the establishment of maternal‐fetal tolerance and thereby the outcome of pregnancy. We investigated whether sHLA‐G levels in SP are associated with polymorphisms in the 3′‐untranslated region (UTR) and UTR haplo...

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Published in:HLA : immune response genetics 2019-10, Vol.94 (4), p.339-346
Main Authors: Craenmehr, Moniek H. C., Haasnoot, Geert W., Drabbels, Jos J. M., Spruyt‐Gerritse, Marijke J., Cao, Milo, Keur, Carin, Kapsenberg, Johanna M., Uyar‐Mercankaya, Merve, Beelen, Els, Meuleman, Tess, Hoorn, Marie‐Louise P., Heidt, Sebastiaan, Claas, Frans H. J., Eikmans, Michael
Format: Article
Language:English
Subjects:
immunology
Original
pregnancy
recurrent miscarriage
seminal plasma
soluble HLA‐G
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Summary:Soluble HLA‐G (sHLA‐G) levels in human seminal plasma (SP) can be diverse and may affect the establishment of maternal‐fetal tolerance and thereby the outcome of pregnancy. We investigated whether sHLA‐G levels in SP are associated with polymorphisms in the 3′‐untranslated region (UTR) and UTR haplotypes of the HLA‐G gene. Furthermore, we compared the HLA‐G genotype distribution and sHLA‐G levels between men, whose partner experienced unexplained recurrent miscarriage (RM), and controls. Soluble HLA‐G levels (n = 156) and HLA‐G genotyping (n = 176) were determined in SP samples. The concentration of sHLA‐G was significantly associated with several single‐nucleotide polymorphisms (SNPs): the 14 base pair (bp) insertion/deletion (indel), +3010, +3142, +3187, +3196, and + 3509. High levels of sHLA‐G were associated with UTR‐1 and low levels with UTR‐2, UTR‐4, and UTR‐7 (P
ISSN:2059-2302
2059-2310
DOI:10.1111/tan.13628