Robust Th1 cellular and humoral responses generated by the Yersinia pestis rF1-V subunit vaccine formulated to contain an agonist of the CD137 pathway do not translate into increased protection against pneumonic plague

Highlights:•Sex bias observed for mice vaccinated with rF1-V subunit plague vaccine. •Sex bias appears independent of antigen-specific antibody or cellular responses. •SA-4-1BBL addition to vaccine formulation increases Th1 cellular responses. •Boosting with the rF1-V vaccine with SA-4-1BBL protects...

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Bibliographic Details
Published in:Vaccine 2019-09, Vol.37 (38), p.5708-5716
Main Authors: Bowen, William, Batra, Lalit, Pulsifer, Amanda R, Yolcu, Esma S, Lawrenz, Matthew B, Shirwan, Haval
Format: Article
Language:English
Subjects:
Adjuvants
Agonists
Allergy and Immunology
Antibiotics
Antibodies
Antigens
Bacteria
Bias
Biological weapons
CD137 antigen
Cytokines
Disease
Effectiveness
Females
Homeostasis
humoral immunity
Immune response (humoral)
Infections
Laboratories
Ligands
Lymphocytes
Lymphocytes T
males
mice
pathogens
Plague
Proteins
Robustness
SA-4-1BBL
Sex
Subunit vaccine
subunit vaccines
Th1-mediated immunity
vaccination
Vaccines
Viral infections
Yersinia pestis
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Summary:Highlights:•Sex bias observed for mice vaccinated with rF1-V subunit plague vaccine. •Sex bias appears independent of antigen-specific antibody or cellular responses. •SA-4-1BBL addition to vaccine formulation increases Th1 cellular responses. •Boosting with the rF1-V vaccine with SA-4-1BBL protects against pneumonic plague. •Balanced cellular/humoral response alone may not predict plague vaccine efficacy.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2019.07.103