Impaired Recognition Memory in Monkeys after Damage Limited to the Hippocampal Region

Monkeys with lesions limited to the hippocampal region (the hippocampus proper, the dentate gyrus, and the subiculum) were impaired on two tasks of recognition memory: delayed nonmatching to sample and the visual paired-comparison task. Recognition memory was impaired in five different groups of mon...

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Bibliographic Details
Published in:The Journal of neuroscience 2000-01, Vol.20 (1), p.451-463
Main Authors: Zola, Stuart M, Squire, Larry R, Teng, Edmond, Stefanacci, Lisa, Buffalo, Elizabeth A, Clark, Robert E
Format: Article
Language:English
Subjects:
Animals
Behavior, Animal
Brain Ischemia - pathology
Brain Ischemia - physiopathology
Excitatory Amino Acid Agonists
Hippocampus - pathology
Hippocampus - physiopathology
Ibotenic Acid
Macaca fascicularis
Male
Nerve Degeneration - chemically induced
Pattern Recognition, Visual - physiology
Photic Stimulation
Psychomotor Performance - physiology
Radio Waves
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Summary:Monkeys with lesions limited to the hippocampal region (the hippocampus proper, the dentate gyrus, and the subiculum) were impaired on two tasks of recognition memory: delayed nonmatching to sample and the visual paired-comparison task. Recognition memory was impaired in five different groups of monkeys, whether the lesions were made by an ischemic procedure, by radio frequency, or by ibotenic acid. The finding that the hippocampal region is essential for normal recognition memory performance is considered in the context of current ideas about the role of the hippocampus in declarative memory.
ISSN:0270-6474
1529-2401
1529-2401
DOI:10.1523/jneurosci.20-01-00451.2000