Immune infiltration in nasopharyngeal carcinoma based on gene expression

Immune infiltration of nasopharyngeal carcinoma (NPC) is closely associated with the patients' prognosis. However, previous studies have not interpreted the difference of infiltrating immune cells in NPC.We comprehensively analyzed the tumor-infiltrating immune cells present in NPC for the firs...

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Bibliographic Details
Published in:Medicine (Baltimore) 2019-09, Vol.98 (39), p.e17311-e17311
Main Authors: Luo, Meng-Si, Huang, Guan-Jiang, Liu, Bao-Xinzi
Format: Article
Language:English
Subjects:
Adult
Algorithms
B-Lymphocytes - immunology
B-Lymphocytes - pathology
CD4-Positive T-Lymphocytes - immunology
CD4-Positive T-Lymphocytes - pathology
China
Correlation of Data
Female
Gene Expression
Humans
Immunologic Memory
Lymphocytes, Tumor-Infiltrating - classification
Lymphocytes, Tumor-Infiltrating - immunology
Lymphocytes, Tumor-Infiltrating - pathology
Macrophages - immunology
Macrophages - pathology
Male
Middle Aged
Nasopharyngeal Carcinoma - diagnosis
Nasopharyngeal Carcinoma - immunology
Nasopharyngeal Carcinoma - pathology
Nasopharyngeal Neoplasms - diagnosis
Nasopharyngeal Neoplasms - immunology
Nasopharyngeal Neoplasms - pathology
Observational Study
Prognosis
Reproducibility of Results
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Summary:Immune infiltration of nasopharyngeal carcinoma (NPC) is closely associated with the patients' prognosis. However, previous studies have not interpreted the difference of infiltrating immune cells in NPC.We comprehensively analyzed the tumor-infiltrating immune cells present in NPC for the first time, which was based on a scientific deconvolution algorithm (CIBERSORT) and the gene expression data of GSE64634. The fractions of 22 immune cells were assessed to reveal the associations between normal samples and NPC samples.Profiles of immune infiltration vary significantly between normal samples and NPC samples, and the variation could characterize the individual differences. NPC samples contained a higher proportion for M1 macrophages, whereas memory B cells and CD4 memory resting T cells were relatively lower.Our data suggest that the differences in the infiltrating immune cells in NPC and these differences would probably facilitate patient consultation and individualized treatment.
ISSN:0025-7974
1536-5964
DOI:10.1097/MD.0000000000017311