Distribution of Aquaporins 1 and 4 in the Central Nervous System

The aquaporins (AQP), a protein family, were first discovered in the early 1990s. The primary role of aquaporins is to facilitate water transport across multiple cell types. In the spinal cord and brain responsible for most of the water diffusion are AQP4 and AQP1. In this paper, we describe the str...

Full description

Saved in:
Bibliographic Details
Published in:Current health sciences journal 2019-01, Vol.45 (2), p.218-226
Main Authors: ROSU, GC, PIRICI, I, GRIGORIE, AA, ISTRATE-OFITERU, AM, IOVAN, L, TUDORICA, V, PIRICI, D
Format: Article
Language:English
Subjects:
Original Paper
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The aquaporins (AQP), a protein family, were first discovered in the early 1990s. The primary role of aquaporins is to facilitate water transport across multiple cell types. In the spinal cord and brain responsible for most of the water diffusion are AQP4 and AQP1. In this paper, we describe the structure, localization and role of this water channel family, especially AQP4 and AQP1. AQP4 is involved in various pathologies such as: stroke, brain tumors, Neuromyelitis optica (NMO), Alzheimer’s Disease (AD), traumatic brain injury, Parkinson’s Disease, hydrocephalus, schizophrenia, epilepsy, major depressive disorder, autism. Brain edema is the most important acute complication of the hypoxic-ischemic and it has no pathogenic treatment. Imaging and histopathology studies have shown that inhibition of AQP4 reduces brain edema.
ISSN:2067-0656
2069-4032
DOI:10.12865/CHSJ.45.02.14