Upregulation of SPDEF is associated with poor prognosis in prostate cancer

SAM pointed domain-containing Ets transcription factor (SPDEF), a member of the ETS transcription factor family, has been associated with prostate cancer development; however, its role in tumour development and progression is controversial. In the present study, SPDEF expression was analysed on a ti...

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Bibliographic Details
Published in:Oncology letters 2019-11, Vol.18 (5), p.5107-5118
Main Authors: Meiners, Jan, Schulz, Katharina, Moller, Katharina, Hoflmayer, Doris, Burdelski, Christoph, Hube-Magg, Claudia, Simon, Ronald, Gobel, Cosima, Hinsch, Andrea, Reiswich, Viktor, Weidemann, Soren, Izbicki, Jacob R, Sauter, Guido, Jacobsen, Frank, Moller-Koop, Christina, Mandelkow, Tim, Blessin, Niclas C, Lutz, Florian, Viehweger, Florian, Lennartz, Maximillian, Fraune, Christoph, Heinzer, Hans, Minner, Sarah, Bonk, Sarah, Huland, Hartwig, Graefen, Markus, Schlomm, Thorsten, Buscheck, Franziska
Format: Article
Language:English
Subjects:
Antigens
Cancer metastasis
Cloning
Development and progression
EDTA
Epithelium
Genes
Genetic research
Medical prognosis
Metastasis
Oncology
Patients
Prognosis
Prostate cancer
Transcription (Genetics)
Transcription factors
Tumors
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Summary:SAM pointed domain-containing Ets transcription factor (SPDEF), a member of the ETS transcription factor family, has been associated with prostate cancer development; however, its role in tumour development and progression is controversial. In the present study, SPDEF expression was analysed on a tissue microarray with >12,000 prostate cancer samples. SPDEF expression levels were higher in most prostate cancer samples than in normal prostate epithelium, suggesting SPDEF was upregulated in cancer. Nuclear SPDEF expression was identified in 80% of prostate cancer samples, and considered weak in 26.4%, moderate in 40.1% and strong in 13.5% of cases. SPDEF positivity was significantly associated with tumour stage, Gleason grade, lymph node metastasis and PSA recurrence (all P
ISSN:1792-1074
1792-1082
DOI:10.3892/ol.2019.10885