Increased pulmonary artery diameter is associated with reduced FEV1 in former World Trade Center workers

Rationale Occupational exposures at the WTC site after September 11, 2001 have been associated with several presumably inflammatory lower airway diseases. Pulmonary arterial enlargement, as suggested by an increased ratio of the diameter of the pulmonary artery to the diameter of the aorta (PAAr) ha...

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Bibliographic Details
Published in:The clinical respiratory journal 2019-10, Vol.13 (10), p.614-623
Main Authors: de la Hoz, Rafael E., Jeon, Yunho, Reeves, Anthony P., San José Estépar, Raúl, Liu, Xiaoyu, Doucette, John T., Celedón, Juan C., Nolan, Anna
Format: Article
Language:English
Subjects:
2001
Bronchodilators
computer‐assisted image processing
Human exposure
multidetector computed tomography
Occupational diseases
occupational medicine
Pulmonary arteries
pulmonary artery
Respiratory diseases
smoke inhalation injury
spirometry
World Trade Center attack
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Summary:Rationale Occupational exposures at the WTC site after September 11, 2001 have been associated with several presumably inflammatory lower airway diseases. Pulmonary arterial enlargement, as suggested by an increased ratio of the diameter of the pulmonary artery to the diameter of the aorta (PAAr) has been reported as a computed tomographic (CT) scan marker of adverse respiratory health outcomes, including WTC‐related disease. In this study, we sought to utilize a novel quantitative CT (QCT) measurement of PAAr to test the hypothesis that an increased ratio is associated with FEV1 below each subject's statistically determined lower limit of normal (FEV1 
ISSN:1752-6981
1752-699X
1752-699X
DOI:10.1111/crj.13067