Caveolin-1 in skin aging - From innocent bystander to major contributor

• Published in: Ageing research reviews 2019-11, Vol.55, p.100959-100959, Article 100959
• Main Authors: Kruglikov, Ilja L, Zhang, Zhuzhen, Scherer, Philipp E
• Format: Article
• Language: English
• Subjects: Aging; Animals; Caveolin 1 - physiology; Fibroblasts - metabolism; Fibroblasts - physiology; Humans; Skin - metabolism; Skin Aging
• ISSN: 1568-1637; 1872-9649; 1872-9649
• DOI: 10.1016/j.arr.2019.100959

Caveolin-1 (Cav-1) appears to be both a pathophysiological contributor and a target in different inflammatory and hyperproliferative skin conditions as well as in skin aging. Skin fibroblasts demonstrate an up-regulation of Cav-1 expression both in chronological and UV-induced aging, and such an up-regulation was observed both in vitro and in vivo. Typical alterations in aging skin involve a reduction of the dermis thickness, a significant expansion of the dermal white adipose tissue as well as modifications of the content and distribution of hyaluronan, impairment of autophagic flux, a reduction of collagen expression and an increase in tissue inflammation. All of these phenomena can be connected with changes in Cav-1 expression in the aging skin. Modified expression of Cav-1 can also significantly influence the mechanical properties of individual skin layers, thus changing the total mechanical stability of the layered composite skin/WAT, leading to typical structural modifications of the skin surface in the aging skin. Selective reduction of Cav-1 expression has the potential to exert anti-aging effects on the skin.