Influence of the Urban Exposome on Birth Weight

The exposome is defined as the totality of environmental exposures from conception onwards. It calls for providing a holistic view of environmental exposures and their effects on human health by evaluating multiple environmental exposures simultaneously during critical periods of life. We evaluated...

Full description

Saved in:
Bibliographic Details
Published in:Environmental health perspectives 2019-04, Vol.127 (4), p.47007
Main Authors: Nieuwenhuijsen, Mark J, Agier, Lydiane, Basagaña, Xavier, Urquiza, Jose, Tamayo-Uria, Ibon, Giorgis-Allemand, Lise, Robinson, Oliver, Siroux, Valérie, Maitre, Léa, de Castro, Montserrat, Valentin, Antonia, Donaire, David, Dadvand, Payam, Aasvang, Gunn Marit, Krog, Norun Hjertager, Schwarze, Per E, Chatzi, Leda, Grazuleviciene, Regina, Andrusaityte, Sandra, Dedele, Audrius, McEachan, Rosie, Wright, John, West, Jane, Ibarluzea, Jesús, Ballester, Ferran, Vrijheid, Martine, Slama, Rémy
Format: Article
Language:English
Subjects:
Air pollution
Algorithms
Birth Weight
Built environment
Buses
Childbirth & labor
Cities
Cohort Studies
Connectivity
Environmental effects
Environmental Exposure - adverse effects
Environmental Exposure - analysis
Environmental health
Environmental indicators
Environmental testing
Environmental toxicology
Europe
Exposome
Exposure
Feature selection
Female
Geographic information systems
Health
Health aspects
Humans
Hypotheses
Infant, Newborn
Land use
Life Sciences
Low birth weight
Meteorology
Nitrogen dioxide
Noise
Noise pollution
Normalized difference vegetative index
Pollutants
Pollution
Population density
Pregnancy
Pregnant women
Public health
Santé publique et épidémiologie
Statistical analysis
Statistical significance
Traffic
Traffic engineering
Traffic volume
Transportation noise
Type 2 diabetes
Urban areas
Urban environments
Weather
Weight
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The exposome is defined as the totality of environmental exposures from conception onwards. It calls for providing a holistic view of environmental exposures and their effects on human health by evaluating multiple environmental exposures simultaneously during critical periods of life. We evaluated the association of the urban exposome with birth weight. We estimated exposure to the urban exposome, including the built environment, air pollution, road traffic noise, meteorology, natural space, and road traffic (corresponding to 24 environmental indicators and 60 exposures) for nearly 32,000 pregnant women from six European birth cohorts. To evaluate associations with either continuous birth weight or term low birth weight (TLBW) risk, we primarily relied on the Deletion-Substitution-Addition (DSA) algorithm, which is an extension of the stepwise variable selection method. Second, we used an exposure-by-exposure exposome-wide association studies (ExWAS) method accounting for multiple hypotheses testing to report associations not adjusted for coexposures. The most consistent statistically significant associations were observed between increasing green space exposure estimated as Normalized Difference Vegetation Index (NDVI) and increased birth weight and decreased TLBW risk. Furthermore, we observed statistically significant associations among presence of public bus line, land use Shannon's Evenness Index, and traffic density and birth weight in our DSA analysis. This investigation is the first large urban exposome study of birth weight that tests many environmental urban exposures. It confirmed previously reported associations for NDVI and generated new hypotheses for a number of built-environment exposures. https://doi.org/10.1289/EHP3971.
ISSN:0091-6765
1552-9924
DOI:10.1289/EHP3971