Association Between Gut Bacterial Diversity and Mortality in Septic Shock Patients: A Cohort Study

BACKGROUND Gut bacterial diversity is decreased in a proportion of patients with septic shock. We attempted to validate the hypothesis that low bacterial diversity increases the risk of mortality. MATERIAL AND METHODS All patients with septic shock seen at 2 medical center from 2016 through 2019 wer...

Full description

Saved in:
Bibliographic Details
Published in:Medical science monitor 2019-10, Vol.25, p.7376-7382
Main Authors: Yin, Lei, Wan, You-Dong, Pan, Xin-Ting, Zhou, Chang-Yong, Lin, Nan, Ma, Cheng-Tai, Yao, Jian, Su, Zhe, Wan, Chao, Yu, Yan-Wu, Zhu, Rui-Xue
Format: Article
Language:English
Subjects:
Aged
Bacteria - genetics
China
Clinical Research
Cohort Studies
Feces - microbiology
Female
Gastrointestinal Microbiome - physiology
Gastrointestinal Tract - microbiology
High-Throughput Nucleotide Sequencing
Humans
Kaplan-Meier Estimate
Male
Microbiota - genetics
Middle Aged
Odds Ratio
Retrospective Studies
Risk Factors
Shock, Septic - microbiology
Shock, Septic - mortality
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:BACKGROUND Gut bacterial diversity is decreased in a proportion of patients with septic shock. We attempted to validate the hypothesis that low bacterial diversity increases the risk of mortality. MATERIAL AND METHODS All patients with septic shock seen at 2 medical center from 2016 through 2019 were included in this cohort study. Total DNA was isolated from stool, and high-throughput sequencing was performed. Clinical data were extracted from patient medical records and hospital databases. Patients were grouped by gut microbiota bacterial diversity (measured by Shannon diversity index) on presentation. We used logistic regression analysis to evaluate the risk of 28-day mortality in septic patients with low Shannon diversity index. RESULTS Of the 150 patients enrolled in this study, low bacterial diversity (Shannon index
ISSN:1643-3750
1234-1010
1643-3750
DOI:10.12659/MSM.916808