Parathyroid hormone reference ranges in healthy individuals classified by vitamin D status

• Published in: Journal of endocrinological investigation 2019-11, Vol.42 (11), p.1353-1360
• Main Authors: Yalla, N., Bobba, G., Guo, G., Stankiewicz, A., Ostlund, R.
• Format: Article
• Language: English
• Subjects: 25-Hydroxyvitamin D; Adult; Aged; Aged, 80 and over; Biomarkers - blood; Endocrinology; Female; Follow-Up Studies; Humans; Hyperparathyroidism; Internal Medicine; Kidney diseases; Male; Medicine; Medicine & Public Health; Menopause; Metabolic Diseases; Middle Aged; Original; Original Article; Parathyroid; Parathyroid hormone; Parathyroid Hormone - blood; Prognosis; Prospective Studies; Reference Values; United States - epidemiology; Vitamin D; Vitamin D - blood; Vitamin D Deficiency - blood; Vitamin D Deficiency - epidemiology; Vitamin deficiency; Vitamins - blood; Young Adult
• ISSN: 1720-8386; 0391-4097; 1720-8386
• DOI: 10.1007/s40618-019-01075-w

Purpose Parathyroid hormone (PTH) concentrations are routinely measured in the diagnosis and management of bone and kidney diseases, but reference ranges can be overestimated if determined in otherwise healthy individuals for whom vitamin D deficiency was not evaluated. We establish PTH reference ranges in apparently healthy, normocalcemic, normophosphatemic individuals categorized by 25-hydroxyvitamin D (25(OH)D) status using the Elecsys ® PTH ( cobas e 601) and Elecsys ® Vitamin D total II electrochemiluminescence immunoassays ( cobas e 411). Methods This prospective, non-interventional study measured PTH in serum from 653 apparently healthy adults [56.7% female; 68.2% white/Caucasian; 28.6% African American; median age 44 years (range 21–83)] from three diverse geographic sites across the USA during summer and winter months. Subjects were classified by concomitant vitamin D sufficiency (≥ 30 ng/mL), insufficiency (> 20 to