Short-term dietary restriction in old mice rejuvenates the aging-induced structural imbalance of gut microbiota

The world’s aging population is growing rapidly. Incidences of multiple pathologies, such as abdominal obesity, cardiovascular and cerebrovascular diseases, type 2 diabetes, and malignant neoplasms, increase sharply with age. Aged individuals possess a significantly shifted composition of gut microb...

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Published in:Biogerontology (Dordrecht) 2019-12, Vol.20 (6), p.837-848
Main Authors: Zeng, Ting, Cui, Hui, Tang, Duozhuang, Garside, George B., Wang, Yiting, Wu, Jianying, Tao, Zhendong, Zhang, Liu, Tao, Si
Format: Article
Language:English
Subjects:
Aging
Aging - metabolism
Animals
Biomedical and Life Sciences
Cell Biology
Cerebrovascular diseases
Developmental Biology
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Dietary restrictions
Digestive system
Energy Intake
Gastrointestinal Microbiome
Gastrointestinal tract
Geriatrics
Geriatrics/Gerontology
Intestinal microflora
Intestine
Life Sciences
Lipid metabolism
Mice
Mice, Inbred C57BL
Microbiota
Obesity
Research Article
Short term
Vascular diseases
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Summary:The world’s aging population is growing rapidly. Incidences of multiple pathologies, such as abdominal obesity, cardiovascular and cerebrovascular diseases, type 2 diabetes, and malignant neoplasms, increase sharply with age. Aged individuals possess a significantly shifted composition of gut microbiota, which is suggested to play important roles in aging associated pathologies. Whether the existing shifted structural composition of microbiota in aged populations can be reverted non-pharmacologically has not been studied so far. Here, we show an intestinal flora imbalance in old C57BL/6J mice with a remarkable dominant proportion of microbes promoting lipid metabolism and inflammation. Intriguingly, short-term (2 months) dietary restriction was enough to significantly revert the imbalance of intestinal flora in aged mice toward a more balanced structural composition as shown in young mice. Our study provides the first evidence that short-term dietary restriction in old mice can restore the already dysfunctional aged gut microbiota. Our study provides the first evidence that short-term dietary restriction in old mice can restore the already dysfunctional aged gut microbiota, which may help ameliorate aging-related disorders plaguing the vast elderly population.
ISSN:1389-5729
1573-6768
DOI:10.1007/s10522-019-09830-5