Innate immunity in allergy

Innate immune system quickly responds to invasion of microbes and foreign substances through the extracellular and intracellular sensing receptors, which recognize distinctive molecular and structural patterns. The recognition of innate immune receptors leads to the induction of inflammatory and ada...

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Bibliographic Details
Published in:Allergy (Copenhagen) 2019-09, Vol.74 (9), p.1660-1674
Main Authors: Maeda, Kazuhiko, Caldez, Matias J., Akira, Shizuo
Format: Article
Language:English
Subjects:
Adaptive Immunity
Adaptor Proteins, Signal Transducing - metabolism
Allergens
Allergies
Animals
Disease Susceptibility - immunology
Humans
Hypersensitivity - diagnosis
Hypersensitivity - etiology
Hypersensitivity - metabolism
Immune response
Immune system
Immunity, Innate
inflammasome
Inflammasomes
Inflammation
Innate immunity
Lectins, C-Type - metabolism
NF-kappa B - metabolism
NLR Proteins - metabolism
pattern recognition receptors
Protein Kinases - metabolism
pyroptosis
Receptors, Pattern Recognition - metabolism
Review
Signal Transduction
Th2 Cells - immunology
Th2 Cells - metabolism
Toll-Like Receptors - metabolism
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Summary:Innate immune system quickly responds to invasion of microbes and foreign substances through the extracellular and intracellular sensing receptors, which recognize distinctive molecular and structural patterns. The recognition of innate immune receptors leads to the induction of inflammatory and adaptive immune responses by activating downstream signaling pathways. Allergy is an immune‐related disease and results from a hypersensitive immune response to harmless substances in the environment. However, less is known about the activation of innate immunity during exposure to allergens. New insights into the innate immune system by sensors and their signaling cascades provide us with more important clues and a framework for understanding allergy disorders. In this review, we will focus on recent advances in the innate immune sensing system.
ISSN:0105-4538
1398-9995
1398-9995
DOI:10.1111/all.13788