Hemoglobinopathies in the North of Morocco: Consanguinity Pilot Study

Consanguinity is a social behavior characterized by the arrangement of marriages between relatives. It coincides generally with the geographic distribution of recessive genetic diseases as it increases the likelihood of homozygosis and, consequently, the incidence of their pathologies in the populat...

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Bibliographic Details
Published in:BioMed research international 2019, Vol.2019 (2019), p.1-7
Main Authors: Ghailani Nourouti, Naima, Barakat, Amina, Zian, Zeineb, Alaoui Ismaili, Fatima Zahra, Laghmich, Achraf, Bennani Mechita, Mohcine
Format: Article
Language:English
Subjects:
Child
Children
Consanguinity
Female
Genetics
Geographical distribution
Grandparents
Health aspects
Hemoglobin
Hemoglobinopathies - epidemiology
Hemoglobinopathy
Humans
Inbreeding
Incidence
Male
Marriage
Morocco - epidemiology
Mortality
Parents & parenting
Pilot Projects
Population
Population studies
Public health
Questionnaires
Social aspects
Social behavior
Studies
Unions
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Summary:Consanguinity is a social behavior characterized by the arrangement of marriages between relatives. It coincides generally with the geographic distribution of recessive genetic diseases as it increases the likelihood of homozygosis and, consequently, the incidence of their pathologies in the population. In this pilot study, we assess the effect of inbreeding on the burden of hemoglobinopathies in Northern Morocco. From January 2016 to December 2018, 197 children born in the studied region to three ancestral generations and diagnosed with hemoglobinopathies were subject to investigation. The rate of consanguinity in the parents’ generation of children with hemoglobinopathies was 50.25%, with first cousin marriages accounting for 68.69% of consanguineous unions (FI = 0.02). The corresponding rates in the general population, based on a sample of N = 900, were 29.67% and 82.02%, respectively. The marriages between first cousins are the most common among the other types of consanguineous unions. Our study propounds that consanguinity substantially contributes to the hemoglobinopathy burden in the studied region and has changed little over time. Refraining from consanguineous marriages and detecting couples at risk could contribute to the reduction of the incidence of genetic diseases in our country.
ISSN:2314-6133
2314-6141
DOI:10.1155/2019/6857417