Effects of vitamin D supplementation on follicular development, gonadotropins and sex hormone concentrations, and insulin resistance in induced polycystic ovary syndrome

Polycystic ovary syndrome (PCOS) as a reproductive disorder disturbs ovarian follicular development, vitamin D stimulated insulin activity, and sex hormone concentrations. This study aimed to examine the effects of vitamin D on ovarian follicular development, insulin resistance, and sex hormone chan...

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Bibliographic Details
Published in:Turkish journal of obstetrics and gynecology 2019-09, Vol.16 (3), p.143-150
Main Authors: Behmanesh, Nasim, Abedelahi, Ali, Charoudeh, Hojjatollah Nozad, Alihemmati, Alireza
Format: Article
Language:English
Subjects:
Androgens
Clinical Investigation
Diabetes
Endocrinology
Estrogens
Infertility
Insulin resistance
Insulin-like growth factors
Kadın Hastalıkları
Medical research
Metabolism
Polycystic ovary syndrome
Studies
Systematic review
Tıp
Vitamin D
Vitamin deficiency
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Summary:Polycystic ovary syndrome (PCOS) as a reproductive disorder disturbs ovarian follicular development, vitamin D stimulated insulin activity, and sex hormone concentrations. This study aimed to examine the effects of vitamin D on ovarian follicular development, insulin resistance, and sex hormone changes in rats with induced PCOS. Forty female Wistar rats were randomly divided into four groups: (1) control, (2) induced PCOS, (3) vitamin D-treated non-PCOS (sham group), (4) vitamin D treated PCOS groups. All rats were then sacrificed under anesthesia and ovarian tissue samples were evaluated histomorphometrically. Blood samples were collected for analyzing the serum concentrations of sex hormones and insulin resistance. The number of atretic follicles at different stages of development increased in the PCOS ovaries (p
ISSN:2149-9322
2149-9330
DOI:10.4274/tjod.galenos.2019.46244