Presynaptic Modulation of Synaptic Transmission and Plasticity by Brain-Derived Neurotrophic Factor in the Developing Hippocampus

• Published in: The Journal of neuroscience 1998-09, Vol.18 (17), p.6830-6839
• Main Authors: Gottschalk, Wolfram, Pozzo-Miller, Lucas D, Figurov, Alexander, Lu, Bai
• Format: Article
• Language: English
• Subjects: Animals; Brain-Derived Neurotrophic Factor - physiology; Hippocampus - growth & development; Hippocampus - physiology; In Vitro Techniques; Long-Term Potentiation - physiology; Presynaptic Terminals - physiology; Rats; Rats, Sprague-Dawley; Synaptic Transmission - physiology
• ISSN: 0270-6474; 1529-2401
• DOI: 10.1523/jneurosci.18-17-06830.1998

In addition to the regulation of neuronal survival and differentiation, neurotrophins may play a role in synapse development and plasticity. Application of brain-derived neurotrophic factor (BDNF) promotes long-term potentiation (LTP) in CA1 synapses of neonatal hippocampus, which otherwise exhibit only short-term potentiation. This is attributable, at least in part, to an attenuation of the synaptic fatigue induced by high-frequency stimulation (HFS). However, the prevention of synaptic fatigue by BDNF could be mediated by an attenuation of synaptic vesicle depletion from presynaptic terminals and/or a reduction of the desensitization of postsynaptic receptors. Here we provide evidence supporting a presynaptic effect of BDNF. The effect of BDNF on synaptic fatigue depended on the stimulation frequency, not on the stimulus duration nor on the number of stimulation pulses. BDNF was only effective when the synapses were stimulated at frequencies >50 Hz. Treatment with BDNF also potentiated paired-pulse facilitation (PPF), a parameter reflecting changes in the properties of presynaptic terminals. This effect of BDNF was restricted only to PPF elicited with interpulse intervals