Transitioning to Fixed-Ratio Combination Therapy: Five Frequently Asked Questions Health Care Providers Should Anticipate From Their Patients

A patient who is overweight with type 2 diabetes and takes multiple oral antihyperglycemic agents has been informed that the current treatment plan is not providing adequate glycemic control and that adding insulin therapy is recommended. However, the patient is concerned about insulin causing weigh...

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Bibliographic Details
Published in:Clinical diabetes 2019-10, Vol.37 (4), p.386-390
Main Authors: Blumer, Ian, Novak, Lucia M., Edelman, Steven, Cavaiola, Tricia Santos
Format: Article
Language:English
Subjects:
Combination therapy
Departments
Diabetes
Drug therapy
GLP-1 receptor agonists
Glucose
Hypoglycemia
Insulin
Weight
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Summary:A patient who is overweight with type 2 diabetes and takes multiple oral antihyperglycemic agents has been informed that the current treatment plan is not providing adequate glycemic control and that adding insulin therapy is recommended. However, the patient is concerned about insulin causing weight gain or leading to hypoglycemia and is looking for a treatment that will avoid or reduce these issues. Taking all of these considerations into account, the health care provider recommends that the patient start insulin and a glucagon-like peptide 1 (GLP-1) receptor agonist given as fixed-ratio combination (FRC) therapy administered with a prefilled pen device that allows for both basal insulin and a GLP-1 receptor agonist to be delivered in a single daily injection.
ISSN:0891-8929
1945-4953
DOI:10.2337/cd18-0102