Acute Stress Facilitates Hippocampal CA1 Metabotropic Glutamate Receptor-Dependent Long-Term Depression

Acute stress affects NMDA receptor (NMDAR)-dependent synaptic plasticity in the CA1 region of the hippocampus, with long-term potentiation and long-term depression (LTD) being, respectively, diminished and facilitated by acute exposure to stress. Here, we examined whether this facilitatory effect of...

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Bibliographic Details
Published in:The Journal of neuroscience 2007-07, Vol.27 (27), p.7130-7135
Main Authors: Chaouloff, Francis, Hemar, Agnes, Manzoni, Olivier
Format: Article
Language:English
Subjects:
Acute Disease
Animals
Brief Communications
Female
Hippocampus - drug effects
Hippocampus - metabolism
Hippocampus - physiology
Life Sciences
Long-Term Synaptic Depression - drug effects
Long-Term Synaptic Depression - physiology
Male
Methoxyhydroxyphenylglycol - analogs & derivatives
Methoxyhydroxyphenylglycol - pharmacology
Neurons and Cognition
Rats
Rats, Sprague-Dawley
Receptors, Metabotropic Glutamate - physiology
Restraint, Physical - methods
Stress, Physiological - metabolism
Stress, Physiological - physiopathology
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Summary:Acute stress affects NMDA receptor (NMDAR)-dependent synaptic plasticity in the CA1 region of the hippocampus, with long-term potentiation and long-term depression (LTD) being, respectively, diminished and facilitated by acute exposure to stress. Here, we examined whether this facilitatory effect of stress on NMDAR-dependent LTD extends to metabotropic glutamate receptor (mGluR)-dependent LTD at Schaffer collateral-CA1 synapses. Application of a low dose (50 microM) of the selective group 1 mGluR agonist (RS)-3,5-dihydroxyphenylglycine (DHPG) promoted LTD in slices from stressed, but not from control, rats. Pretreatment of stressed rats with the glucocorticoid receptor (GR) antagonist RU38486 prevented the facilitation of DHPG-induced LTD (DHPG-LTD), indicating the involvement of corticosterone secretion and, in turn, stimulation of GRs. Finally, pretreatment of slices with an mGluR1, but not an mGluR5, antagonist blunted the sensitizing effect of stress on DHPG-LTD. These results indicate that acute stress, through corticosterone stimulation of GRs, facilitates the expression of mGluR1-dependent DHPG-LTD in the hippocampal CA1 region.
ISSN:0270-6474
1529-2401
DOI:10.1523/JNEUROSCI.1150-07.2007