Treatment with Molgramostim (Recombinant Human Granulocyte-Macrophage Colony Stimulating Factor, Rhugm-Csf, Mielogen) and Lenograstim (Granulocyte-Colony Stimulating Factor) Improves Experimental Colitis in Rats

Background/Aim. Treatment with growth factors could be beneficial in both inflammatory bowel disease and experimental colitis. The aim of this study was to investigate the effect of Colony Stimulating Factor (CSF), and Recombinant Human (rHu) Granulocyte Stimulating Factor (GSF) in experimental coli...

Full description

Saved in:
Bibliographic Details
Published in:BioMed research international 2019, Vol.2019 (2019), p.1-8
Main Authors: Triantafillidis, John K., Nomikos, Alexandros, Pittaras, Theodoros, Sideris, Michail, Korontzi, Maria, Chrysikos, Dimosthenis, Barbatis, Calypso, Papalois, Apostolos E., Triantafyllidi, Eleni
Format: Article
Language:English
Subjects:
Animals
Colitis
Colitis - drug therapy
Colon
Colonies
Colony-stimulating factor
Disease Models, Animal
Euthanasia
Gastroenterology
Granulocyte Colony-Stimulating Factor - pharmacology
Granulocyte-macrophage colony stimulating factor
Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology
Granulocytes
Granulocytes - drug effects
Growth factors
Humans
Inflammatory bowel disease
Inflammatory bowel diseases
Intestine
Lenograstim - pharmacology
Leukocytes (granulocytic)
Macrophage Colony-Stimulating Factor - pharmacology
Macrophages
Male
Malondialdehyde
Neutrophils
Oxidative stress
Physiology
Prednisolone
Rats
Rats, Wistar
Recombinant Proteins - pharmacology
Rodents
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background/Aim. Treatment with growth factors could be beneficial in both inflammatory bowel disease and experimental colitis. The aim of this study was to investigate the effect of Colony Stimulating Factor (CSF), and Recombinant Human (rHu) Granulocyte Stimulating Factor (GSF) in experimental colitis in rats. Methods. Experimental colitis was induced in 62 male Wistar rats, divided into 9 groups, using 2,4,6-trinitrobenzensulfonic acid (TNBS). Group 1: Ten rats with colitis without treatment (control group). Euthanasia after 15 days. Group 2: Ten animals with colitis without treatment (control group). Euthanasia after 30 days. Group 3: Six animals with colitis. Immediate treatment with CSF. Euthanasia after 19 days. Group 4: Six animals with colitis. Treatment started 7 days after the induction of colitis. Animals were kept for 19 days. Group 5: Six animals with colitis. Treatment started 2 weeks after the induction of colitis. Group 6: Six animals with colitis, the same as in group 3. Treatment with GSF. Group 7: Six animals with colitis, the same as in group 4. Treatment with GSF. Group 8. Six animals with colitis, the same as in group 5. Treatment with GSF. Group 9: Six animals with colitis. Immediate treatment with prednisolone. Euthanasia after 15 days. Results. CSF and GSF administration significantly improved the histological score (P
ISSN:2314-6133
2314-6141
DOI:10.1155/2019/8298192