Gamma Glutamyl Transferase Activity is Associated With Both Paraoxonase Activity and Aortic Stiffness in Hypertensive Patients

• Published in: Journal of clinical laboratory analysis 2015-09, Vol.29 (5), p.390-396
• Main Authors: Gözükara, Mehmet Yavuz, Börekçi, Abdurrezzak, Gür, Mustafa, Aksoy, Nurten, Şeker, Taner, Kaypaklı, Onur, Uçar, Hakan, Türkoğlu, Caner, Koç, Mevlüt, Makca, İlyas, Akyol, Selahattin, Selek, Şahbettin, Çaylı, Murat
• Format: Article
• Language: English
• Subjects: Antioxidants; Aorta - physiopathology; aortic stiffness; Aryldialkylphosphatase - blood; Cardiovascular disease; Cohort Studies; CRP; Enzymes; Essential Hypertension; Female; gamma-Glutamyltransferase - blood; GGT; Humans; Hypertension; Hypertension - physiopathology; Male; Middle Aged; Original; paraoxonase; Pulse Wave Analysis; PWV; Vascular Stiffness - physiology
• ISSN: 0887-8013; 1098-2825
• DOI: 10.1002/jcla.21785

Background We aimed to investigate relationship between gamma glutamyl transferase (GGT) activity with paraoxonase 1 (PON1) activity and aortic stiffness (AS) parameters such as pulse wave velocity (PWV) and augmentation index (AIx). Methods Measurements were obtained from 324 patients with newly diagnosed essential hypertension (mean age: 55.0 ± 8.2 years). The patients were divided into two groups according to their median GGT values. PWV and AIx were calculated using the single‐point method via the Mobil‐O‐Graph® ARCsolver algorithm. Results PWV, Aix, and high‐sensitive C‐reactive protein (hs‐CRP) values were higher and PON1 activity values were lower in GGThigh group compared with GGTlow group (P < 0.05, for all). Multiple linear regression analysis showed that GGT activity was independently associated with PWV (β = 0.496, P < 0.001) and PON1 activity (β = −0.343, P < 0.001) as well as hs‐CRP (β = 0.334, P < 0.001). Conclusion These results may support that increased GGT activity would be associated with both impaired antioxidant system and increased AS in hypertensive patients.