Novel Role for Claudin‐11 in the Regulation of Osteoblasts via Modulation of ADAM10‐Mediated Notch Signaling

ABSTRACT The claudin (Cldn) family comprises 27 members of 20 to 34 kDa transmembrane tight junction proteins. In addition to Cldns’ established canonical role as barriers controlling paracellular flow of molecules, a distinct noncanonical role for them as mediators of cell signaling is now emerging...

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Bibliographic Details
Published in:Journal of bone and mineral research 2019-10, Vol.34 (10), p.1910-1922
Main Authors: Lindsey, Richard C, Xing, Weirong, Pourteymoor, Sheila, Godwin, Catrina, Gow, Alexander, Mohan, Subburaman
Format: Article
Language:English
Subjects:
ADAM10
Bone growth
Bone histomorphometry
Bone resorption
Cancellous bone
Cell differentiation
Cell surface
CLAUDIN‐11
Immunohistochemistry
NOTCH
Osteoblastogenesis
OSTEOBLASTS
Osteogenesis
Spine
TIGHT JUNCTIONS
Vertebrae
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Summary:ABSTRACT The claudin (Cldn) family comprises 27 members of 20 to 34 kDa transmembrane tight junction proteins. In addition to Cldns’ established canonical role as barriers controlling paracellular flow of molecules, a distinct noncanonical role for them as mediators of cell signaling is now emerging. In our studies evaluating Cldn family expression levels during osteoblast differentiation, Cldn‐11 showed the largest increase (60‐fold). Immunohistochemistry studies revealed high Cldn‐11 expression in trabecular (Tb) bone lining cells. Micro‐CT analysis of femurs and vertebrae of Cldn‐11 knock‐out (KO) mice at 12 weeks of age exhibited a 40% (p 
ISSN:0884-0431
1523-4681
DOI:10.1002/jbmr.3763