The Effect of Atorvastatin on Preventing Noise-Induced Hearing Loss: An Experimental Study

Noise-induced hearing loss (NIHL) is a common, irreversible occupational disease. Statins have recently been proposed to prevent NIHL. To assess the effect of atorvastatin for the prevention of NIHL in rats. In this experimental study, forty 2-3-month-old Wistar male rats were divided into 5 groups...

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Bibliographic Details
Published in:international journal of occupational and environmental medicine 2016-01, Vol.7 (1), p.15-21
Main Authors: Jahani, L, Mehrparvar, A H, Esmailidehaj, M, Rezvani, M E, Moghbelolhossein, B, Razmjooei, Z
Format: Article
Language:English
Subjects:
Animals
Atorvastatin Calcium - administration & dosage
Atorvastatin Calcium - pharmacology
Hearing Loss, Noise-Induced - drug therapy
Hearing Loss, Noise-Induced - physiopathology
Hearing Loss, Noise-Induced - prevention & control
Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use
Male
Noise - adverse effects
Occupational Diseases - drug therapy
Occupational Diseases - prevention & control
Original
Otoacoustic Emissions, Spontaneous - drug effects
Otoacoustic Emissions, Spontaneous - physiology
Rats
Rats, Wistar
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Summary:Noise-induced hearing loss (NIHL) is a common, irreversible occupational disease. Statins have recently been proposed to prevent NIHL. To assess the effect of atorvastatin for the prevention of NIHL in rats. In this experimental study, forty 2-3-month-old Wistar male rats were divided into 5 groups of 8 animals. 3 groups of rats received atorvastatin at doses of 5, 25, and 50 mg/kg daily for 14 days. The 4th group of rats received normal saline; another group was the control group. After 2 weeks of treatment, the rats were exposed to broad-band noise (125-20 000 Hz) at 110 dB-SPL intensity for 2 hours. Response amplitude of all ears at 5 frequencies was assessed by distortion product otoacoustic emissions (DP-OAE) at baseline, 2 hours, and 2 weeks after the exposure. Response amplitude was significantly decreased at all frequencies immediately after exposure to noise in all studied groups. The amplitude increased after 72 hours to a level higher than temporary threshold shift (TTS); this change was only significant in the group received 5 mg/kg atorvastatin. Low dose atorvastatin (5 mg/kg) used before exposure to noise can probably prevent NIHL in rats. This effect was not observed with higher doses of the drug.
ISSN:2008-6520
2008-6814
DOI:10.15171/ijoem.2016.627