Enhanced serum levels of matrix Gla protein and bone morphogenetic protein in acute coronary syndrome patients

Background Vascular calcification has been found to be associated with increased risk of cardiovascular (CV) morbidity and mortality. Various bone‐associated proteins have been suggested to be related with this process. In this study, we aimed to evaluate whether serum levels of bone morphogenic pro...

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Bibliographic Details
Published in:Journal of clinical laboratory analysis 2018-03, Vol.32 (3), p.n/a
Main Authors: Buyukterzi, Zafer, Can, Ummugulsum, Alpaydin, Sertac, Guzelant, Asuman, Karaarslan, Sukru, Mustu, Mehmet, Kocyigit, Duygu, Gurses, Kadri Murat
Format: Article
Language:English
Subjects:
acute coronary syndrome
Acute Coronary Syndrome - blood
Acute Coronary Syndrome - epidemiology
Acute coronary syndromes
Aged
Angiography
Atherosclerosis
biomarker
Biomarkers - blood
Bone matrix
bone morphogenetic protein
Bone Morphogenetic Protein 4 - blood
Bone morphogenetic proteins
Calcification (ectopic)
Calcium-Binding Proteins - blood
Cardiovascular diseases
Cholesterol
Cohort Studies
Coronary artery
Coronary vessels
Extracellular Matrix Proteins - blood
Female
Heart
High density lipoprotein
Humans
Ischemia
Male
Matrix Gla Protein
Medical imaging
Middle Aged
Morbidity
Proteins
Risk factors
Serum levels
Ventricle
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Summary:Background Vascular calcification has been found to be associated with increased risk of cardiovascular (CV) morbidity and mortality. Various bone‐associated proteins have been suggested to be related with this process. In this study, we aimed to evaluate whether serum levels of bone morphogenic protein‐4 (BMP‐4) and matrix Gla protein (MGP) differed in patients who were found to have normal epicardial coronary arteries or a culprit lesion in the coronary angiography leading to acute coronary syndrome (ACS). Methods Patients admitted to emergency department with the diagnosis of ACS who underwent primary percutaneous coronary intervention (PCI) between October 2015 and April 2016 were consecutively recruited as the patient group. Age and gender‐matched subjects who underwent coronary angiography following non‐invasive ischemia assessment made the control group. Results A total of 90 subjects (63.00±14.02 years, 70% male) were included in this study. MGP (
ISSN:0887-8013
1098-2825
DOI:10.1002/jcla.22278