Loading…
Relationship between C‐reactive protein/albumin ratio and coronary artery disease severity in patients with stable angina pectoris
Background Syntax score (SS), which is an angiographic tool used in grading the complexity of coronary artery disease (CAD), has prognostic importance in coronary artery disease (CAD) and provides important information regarding selection of revascularization strategy. C‐reactive protein (CRP) and a...
Saved in:
| Published in: | Journal of clinical laboratory analysis 2018-09, Vol.32 (7), p.e22457-n/a |
|---|---|
| Main Authors: | , , , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c4487-17c68eed10fed13028724368111ded1f17baf21157f9a7c9313e32e1305372083 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c4487-17c68eed10fed13028724368111ded1f17baf21157f9a7c9313e32e1305372083 |
| container_end_page | n/a |
| container_issue | 7 |
| container_start_page | e22457 |
| container_title | Journal of clinical laboratory analysis |
| container_volume | 32 |
| creator | Karabağ, Yavuz Çağdaş, Metin Rencuzogullari, Ibrahim Karakoyun, Süleyman Artaç, İnanç İliş, Doğan Atalay, Eray Yesin, Mahmut Gürsoy, Mustafa Ozan Halil Tanboğa, Ibrahim |
| description | Background
Syntax score (SS), which is an angiographic tool used in grading the complexity of coronary artery disease (CAD), has prognostic importance in coronary artery disease (CAD) and provides important information regarding selection of revascularization strategy. C‐reactive protein (CRP) and albumin are indicators of inflammation, and high levels of them are associated with high SS. We aimed to investigate whether baseline CRP to albumin ratio C‐Reactive Protein/Albumin Ratio (CAR), an easily available and novel inflammatory marker, is associated with SS.
Method
A total 403 consecutive patients with stabile angina pectoris, who underwent coronary angiography for suspected CAD from January 2015 to June 2016, were classified into two groups, low SS (≤22) and intermediate‐high SS (>22).
Results
C‐Reactive Protein/Albumin Ratio was significantly higher in patients with intermediate‐high SS group (P 6.3 predicted an intermediate‐high SS with sensitivity and specificity of 86.8% and 43.4%, respectively.
Conclusion
C‐Reactive Protein/Albumin Ratio was more tightly associated with the complexity and severity of CAD than CRP and albumin alone and was found to be an independent predictor for intermediate‐high SS group. |
| doi_str_mv | 10.1002/jcla.22457 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6816976</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2027071150</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4487-17c68eed10fed13028724368111ded1f17baf21157f9a7c9313e32e1305372083</originalsourceid><addsrcrecordid>eNp9kc2KFDEUhYMoTju68QEk4GYQeiZJVVdSG2Fo_KVBEF2HVOrWdJp0UiapbnrnwgfwGX0Sb9vjoC7c5ELy5dxzOIQ85eySMyauNtabSyHqhbxHZpy1ai6UWNwnM6aUnCvGqzPyKOcNY0y1vHlIzkTbNFKKeka-fQRvioshr91IOyh7gECXP75-T2BscTugY4oFXLgyvpu2LtB05KkJPbUxxWDSgZpUAEfvMpgMNMMOkisHivSINISS6d6VNc3FdB7w840Lho5gS0wuPyYPBuMzPLmd5-Tz61eflm_nqw9v3i2vV3Nb15iES9sogJ6zAY-KCYURqkZxznu8GLjszCA4X8ihNdK2Fa-gEoDkopKCqeqcvDzpjlO3hd6ir2S8HpPbYgodjdN_vwS31jdxp3FH08oGBS5uBVL8MkEueuuyBe9NgDhlLZiQTKIDhujzf9BNnFLAeFpwLEag_xqpFyfKpphzguHODGf6WK4-lqt_lYvwsz_t36G_20SAn4C983D4j5R-v1xdn0R_AlKCstI</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2108823024</pqid></control><display><type>article</type><title>Relationship between C‐reactive protein/albumin ratio and coronary artery disease severity in patients with stable angina pectoris</title><source>Open Access: PubMed Central</source><creator>Karabağ, Yavuz ; Çağdaş, Metin ; Rencuzogullari, Ibrahim ; Karakoyun, Süleyman ; Artaç, İnanç ; İliş, Doğan ; Atalay, Eray ; Yesin, Mahmut ; Gürsoy, Mustafa Ozan ; Halil Tanboğa, Ibrahim</creator><creatorcontrib>Karabağ, Yavuz ; Çağdaş, Metin ; Rencuzogullari, Ibrahim ; Karakoyun, Süleyman ; Artaç, İnanç ; İliş, Doğan ; Atalay, Eray ; Yesin, Mahmut ; Gürsoy, Mustafa Ozan ; Halil Tanboğa, Ibrahim</creatorcontrib><description>Background
Syntax score (SS), which is an angiographic tool used in grading the complexity of coronary artery disease (CAD), has prognostic importance in coronary artery disease (CAD) and provides important information regarding selection of revascularization strategy. C‐reactive protein (CRP) and albumin are indicators of inflammation, and high levels of them are associated with high SS. We aimed to investigate whether baseline CRP to albumin ratio C‐Reactive Protein/Albumin Ratio (CAR), an easily available and novel inflammatory marker, is associated with SS.
Method
A total 403 consecutive patients with stabile angina pectoris, who underwent coronary angiography for suspected CAD from January 2015 to June 2016, were classified into two groups, low SS (≤22) and intermediate‐high SS (>22).
Results
C‐Reactive Protein/Albumin Ratio was significantly higher in patients with intermediate‐high SS group (P < .001). In multivariate regression analysis, CAR remained an independent predictor of intermediate‐high SS group together with hypertension and LDL. The predictive performance of CAR, CRP, and albumin was compared by ROC curve analysis. CAR surpassed CRP and albumin in predicting intermediate‐high SS group. CAR >6.3 predicted an intermediate‐high SS with sensitivity and specificity of 86.8% and 43.4%, respectively.
Conclusion
C‐Reactive Protein/Albumin Ratio was more tightly associated with the complexity and severity of CAD than CRP and albumin alone and was found to be an independent predictor for intermediate‐high SS group.</description><identifier>ISSN: 0887-8013</identifier><identifier>EISSN: 1098-2825</identifier><identifier>DOI: 10.1002/jcla.22457</identifier><identifier>PMID: 29667724</identifier><language>eng</language><publisher>United States: John Wiley & Sons, Inc</publisher><subject>Aged ; Albumin ; Angina ; Angina pectoris ; Angina, Stable - complications ; Angina, Stable - epidemiology ; Angiography ; Biomarkers - blood ; C-Reactive Protein - analysis ; Cardiovascular disease ; Coronary artery ; Coronary Artery Disease - blood ; Coronary Artery Disease - complications ; Coronary Artery Disease - epidemiology ; coronary artery disease severity ; Coronary vessels ; C‐reactive protein ; C‐reactive protein/albumin ratio ; Female ; Heart diseases ; Humans ; Inflammation ; Low density lipoprotein ; Male ; Middle Aged ; Proteins ; ROC Curve ; Serum Albumin - analysis ; Severity of Illness Index ; stable angina pectoris ; syntax score</subject><ispartof>Journal of clinical laboratory analysis, 2018-09, Vol.32 (7), p.e22457-n/a</ispartof><rights>2018 Wiley Periodicals, Inc.</rights><rights>Copyright © 2018 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4487-17c68eed10fed13028724368111ded1f17baf21157f9a7c9313e32e1305372083</citedby><cites>FETCH-LOGICAL-c4487-17c68eed10fed13028724368111ded1f17baf21157f9a7c9313e32e1305372083</cites><orcidid>0000-0002-8156-315X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6816976/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6816976/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29667724$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Karabağ, Yavuz</creatorcontrib><creatorcontrib>Çağdaş, Metin</creatorcontrib><creatorcontrib>Rencuzogullari, Ibrahim</creatorcontrib><creatorcontrib>Karakoyun, Süleyman</creatorcontrib><creatorcontrib>Artaç, İnanç</creatorcontrib><creatorcontrib>İliş, Doğan</creatorcontrib><creatorcontrib>Atalay, Eray</creatorcontrib><creatorcontrib>Yesin, Mahmut</creatorcontrib><creatorcontrib>Gürsoy, Mustafa Ozan</creatorcontrib><creatorcontrib>Halil Tanboğa, Ibrahim</creatorcontrib><title>Relationship between C‐reactive protein/albumin ratio and coronary artery disease severity in patients with stable angina pectoris</title><title>Journal of clinical laboratory analysis</title><addtitle>J Clin Lab Anal</addtitle><description>Background
Syntax score (SS), which is an angiographic tool used in grading the complexity of coronary artery disease (CAD), has prognostic importance in coronary artery disease (CAD) and provides important information regarding selection of revascularization strategy. C‐reactive protein (CRP) and albumin are indicators of inflammation, and high levels of them are associated with high SS. We aimed to investigate whether baseline CRP to albumin ratio C‐Reactive Protein/Albumin Ratio (CAR), an easily available and novel inflammatory marker, is associated with SS.
Method
A total 403 consecutive patients with stabile angina pectoris, who underwent coronary angiography for suspected CAD from January 2015 to June 2016, were classified into two groups, low SS (≤22) and intermediate‐high SS (>22).
Results
C‐Reactive Protein/Albumin Ratio was significantly higher in patients with intermediate‐high SS group (P < .001). In multivariate regression analysis, CAR remained an independent predictor of intermediate‐high SS group together with hypertension and LDL. The predictive performance of CAR, CRP, and albumin was compared by ROC curve analysis. CAR surpassed CRP and albumin in predicting intermediate‐high SS group. CAR >6.3 predicted an intermediate‐high SS with sensitivity and specificity of 86.8% and 43.4%, respectively.
Conclusion
C‐Reactive Protein/Albumin Ratio was more tightly associated with the complexity and severity of CAD than CRP and albumin alone and was found to be an independent predictor for intermediate‐high SS group.</description><subject>Aged</subject><subject>Albumin</subject><subject>Angina</subject><subject>Angina pectoris</subject><subject>Angina, Stable - complications</subject><subject>Angina, Stable - epidemiology</subject><subject>Angiography</subject><subject>Biomarkers - blood</subject><subject>C-Reactive Protein - analysis</subject><subject>Cardiovascular disease</subject><subject>Coronary artery</subject><subject>Coronary Artery Disease - blood</subject><subject>Coronary Artery Disease - complications</subject><subject>Coronary Artery Disease - epidemiology</subject><subject>coronary artery disease severity</subject><subject>Coronary vessels</subject><subject>C‐reactive protein</subject><subject>C‐reactive protein/albumin ratio</subject><subject>Female</subject><subject>Heart diseases</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Low density lipoprotein</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Proteins</subject><subject>ROC Curve</subject><subject>Serum Albumin - analysis</subject><subject>Severity of Illness Index</subject><subject>stable angina pectoris</subject><subject>syntax score</subject><issn>0887-8013</issn><issn>1098-2825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kc2KFDEUhYMoTju68QEk4GYQeiZJVVdSG2Fo_KVBEF2HVOrWdJp0UiapbnrnwgfwGX0Sb9vjoC7c5ELy5dxzOIQ85eySMyauNtabSyHqhbxHZpy1ai6UWNwnM6aUnCvGqzPyKOcNY0y1vHlIzkTbNFKKeka-fQRvioshr91IOyh7gECXP75-T2BscTugY4oFXLgyvpu2LtB05KkJPbUxxWDSgZpUAEfvMpgMNMMOkisHivSINISS6d6VNc3FdB7w840Lho5gS0wuPyYPBuMzPLmd5-Tz61eflm_nqw9v3i2vV3Nb15iES9sogJ6zAY-KCYURqkZxznu8GLjszCA4X8ihNdK2Fa-gEoDkopKCqeqcvDzpjlO3hd6ir2S8HpPbYgodjdN_vwS31jdxp3FH08oGBS5uBVL8MkEueuuyBe9NgDhlLZiQTKIDhujzf9BNnFLAeFpwLEag_xqpFyfKpphzguHODGf6WK4-lqt_lYvwsz_t36G_20SAn4C983D4j5R-v1xdn0R_AlKCstI</recordid><startdate>201809</startdate><enddate>201809</enddate><creator>Karabağ, Yavuz</creator><creator>Çağdaş, Metin</creator><creator>Rencuzogullari, Ibrahim</creator><creator>Karakoyun, Süleyman</creator><creator>Artaç, İnanç</creator><creator>İliş, Doğan</creator><creator>Atalay, Eray</creator><creator>Yesin, Mahmut</creator><creator>Gürsoy, Mustafa Ozan</creator><creator>Halil Tanboğa, Ibrahim</creator><general>John Wiley & Sons, Inc</general><general>John Wiley and Sons Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-8156-315X</orcidid></search><sort><creationdate>201809</creationdate><title>Relationship between C‐reactive protein/albumin ratio and coronary artery disease severity in patients with stable angina pectoris</title><author>Karabağ, Yavuz ; Çağdaş, Metin ; Rencuzogullari, Ibrahim ; Karakoyun, Süleyman ; Artaç, İnanç ; İliş, Doğan ; Atalay, Eray ; Yesin, Mahmut ; Gürsoy, Mustafa Ozan ; Halil Tanboğa, Ibrahim</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4487-17c68eed10fed13028724368111ded1f17baf21157f9a7c9313e32e1305372083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Aged</topic><topic>Albumin</topic><topic>Angina</topic><topic>Angina pectoris</topic><topic>Angina, Stable - complications</topic><topic>Angina, Stable - epidemiology</topic><topic>Angiography</topic><topic>Biomarkers - blood</topic><topic>C-Reactive Protein - analysis</topic><topic>Cardiovascular disease</topic><topic>Coronary artery</topic><topic>Coronary Artery Disease - blood</topic><topic>Coronary Artery Disease - complications</topic><topic>Coronary Artery Disease - epidemiology</topic><topic>coronary artery disease severity</topic><topic>Coronary vessels</topic><topic>C‐reactive protein</topic><topic>C‐reactive protein/albumin ratio</topic><topic>Female</topic><topic>Heart diseases</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Low density lipoprotein</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Proteins</topic><topic>ROC Curve</topic><topic>Serum Albumin - analysis</topic><topic>Severity of Illness Index</topic><topic>stable angina pectoris</topic><topic>syntax score</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Karabağ, Yavuz</creatorcontrib><creatorcontrib>Çağdaş, Metin</creatorcontrib><creatorcontrib>Rencuzogullari, Ibrahim</creatorcontrib><creatorcontrib>Karakoyun, Süleyman</creatorcontrib><creatorcontrib>Artaç, İnanç</creatorcontrib><creatorcontrib>İliş, Doğan</creatorcontrib><creatorcontrib>Atalay, Eray</creatorcontrib><creatorcontrib>Yesin, Mahmut</creatorcontrib><creatorcontrib>Gürsoy, Mustafa Ozan</creatorcontrib><creatorcontrib>Halil Tanboğa, Ibrahim</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of clinical laboratory analysis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Karabağ, Yavuz</au><au>Çağdaş, Metin</au><au>Rencuzogullari, Ibrahim</au><au>Karakoyun, Süleyman</au><au>Artaç, İnanç</au><au>İliş, Doğan</au><au>Atalay, Eray</au><au>Yesin, Mahmut</au><au>Gürsoy, Mustafa Ozan</au><au>Halil Tanboğa, Ibrahim</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship between C‐reactive protein/albumin ratio and coronary artery disease severity in patients with stable angina pectoris</atitle><jtitle>Journal of clinical laboratory analysis</jtitle><addtitle>J Clin Lab Anal</addtitle><date>2018-09</date><risdate>2018</risdate><volume>32</volume><issue>7</issue><spage>e22457</spage><epage>n/a</epage><pages>e22457-n/a</pages><issn>0887-8013</issn><eissn>1098-2825</eissn><abstract>Background
Syntax score (SS), which is an angiographic tool used in grading the complexity of coronary artery disease (CAD), has prognostic importance in coronary artery disease (CAD) and provides important information regarding selection of revascularization strategy. C‐reactive protein (CRP) and albumin are indicators of inflammation, and high levels of them are associated with high SS. We aimed to investigate whether baseline CRP to albumin ratio C‐Reactive Protein/Albumin Ratio (CAR), an easily available and novel inflammatory marker, is associated with SS.
Method
A total 403 consecutive patients with stabile angina pectoris, who underwent coronary angiography for suspected CAD from January 2015 to June 2016, were classified into two groups, low SS (≤22) and intermediate‐high SS (>22).
Results
C‐Reactive Protein/Albumin Ratio was significantly higher in patients with intermediate‐high SS group (P < .001). In multivariate regression analysis, CAR remained an independent predictor of intermediate‐high SS group together with hypertension and LDL. The predictive performance of CAR, CRP, and albumin was compared by ROC curve analysis. CAR surpassed CRP and albumin in predicting intermediate‐high SS group. CAR >6.3 predicted an intermediate‐high SS with sensitivity and specificity of 86.8% and 43.4%, respectively.
Conclusion
C‐Reactive Protein/Albumin Ratio was more tightly associated with the complexity and severity of CAD than CRP and albumin alone and was found to be an independent predictor for intermediate‐high SS group.</abstract><cop>United States</cop><pub>John Wiley & Sons, Inc</pub><pmid>29667724</pmid><doi>10.1002/jcla.22457</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-8156-315X</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0887-8013 |
| ispartof | Journal of clinical laboratory analysis, 2018-09, Vol.32 (7), p.e22457-n/a |
| issn | 0887-8013 1098-2825 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6816976 |
| source | Open Access: PubMed Central |
| subjects | Aged Albumin Angina Angina pectoris Angina, Stable - complications Angina, Stable - epidemiology Angiography Biomarkers - blood C-Reactive Protein - analysis Cardiovascular disease Coronary artery Coronary Artery Disease - blood Coronary Artery Disease - complications Coronary Artery Disease - epidemiology coronary artery disease severity Coronary vessels C‐reactive protein C‐reactive protein/albumin ratio Female Heart diseases Humans Inflammation Low density lipoprotein Male Middle Aged Proteins ROC Curve Serum Albumin - analysis Severity of Illness Index stable angina pectoris syntax score |
| title | Relationship between C‐reactive protein/albumin ratio and coronary artery disease severity in patients with stable angina pectoris |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-29T00%3A50%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Relationship%20between%20C%E2%80%90reactive%20protein/albumin%20ratio%20and%20coronary%20artery%20disease%20severity%20in%20patients%20with%20stable%20angina%20pectoris&rft.jtitle=Journal%20of%20clinical%20laboratory%20analysis&rft.au=Karaba%C4%9F,%20Yavuz&rft.date=2018-09&rft.volume=32&rft.issue=7&rft.spage=e22457&rft.epage=n/a&rft.pages=e22457-n/a&rft.issn=0887-8013&rft.eissn=1098-2825&rft_id=info:doi/10.1002/jcla.22457&rft_dat=%3Cproquest_pubme%3E2027071150%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c4487-17c68eed10fed13028724368111ded1f17baf21157f9a7c9313e32e1305372083%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2108823024&rft_id=info:pmid/29667724&rfr_iscdi=true |