Magnetic Resonance Elastography of kidneys: SE‐EPI MRE reproducibility and its comparison to GRE MRE

• Published in: NMR in biomedicine 2019-11, Vol.32 (11), p.e4141-n/a
• Main Authors: Gandhi, Deep, Kalra, Prateek, Raterman, Brian, Mo, Xiaokui, Dong, Huiming, Kolipaka, Arunark
• Format: Article
• Language: English
• Subjects: Biological products; Correlation analysis; kidney MRE; kidney stiffness; Kidneys; Magnetic resonance imaging; MR Elastography of kidneys; Neuroimaging; Reproducibility; Resonance; Stiffness
• ISSN: 0952-3480; 1099-1492
• DOI: 10.1002/nbm.4141

The purpose of this study is 1) to demonstrate reproducibility of spin echo‐echo planar imaging (SE‐EPI) magnetic resonance elastography (MRE) to estimate kidney stiffness; and 2) to compare SE‐EPI MRE and gradient recalled echo (GRE) MRE‐derived stiffness estimations in various anatomical regions of the kidney. Kidney MRE was performed on 33 healthy subjects (8 for SE‐EPI MRE reproducibility and 25 for comparison with GRE MRE; age range: 22–66 years) in a 3 T MRI scanner. To demonstrate SE‐EPI MRE reproducibility, subjects were scanned for the first scan and then asked to leave the scan room and repositioned again for the second (repeat) scan. Similar set‐up was used for GRE MRE as well. The displacement data was then processed to obtain overall stiffness estimates of the kidney. Concordance correlation analyses were performed to determine SE‐EPI MRE reproducibility and agreement between GRE MRE and SE‐EPI MRE derived stiffness. A high concordance correlation (ρc = 0.95; p‐value