CD62P and P10 as predictive markers for assessing the efficacy of hemodialysis in treating end‐stage renal disease

• Published in: Journal of clinical laboratory analysis 2019-02, Vol.33 (2), p.e22662-n/a
• Main Authors: Yu, Ji‐Rong, Wang, Feng‐Mei, Xu, Sheng‐Chun, Gao, Min
• Format: Article
• Language: English
• Subjects: Adult; Aged; Albumin; Biomarkers - blood; Blood Urea Nitrogen; CD62P; Correlation analysis; Creatinine; Creatinine - blood; efficacy; end‐stage renal disease; Female; Fibrinogen; flow cytometry; Hemodialysis; Hemoglobin; Humans; Kidney diseases; Kidney Failure, Chronic - blood; Kidney Failure, Chronic - epidemiology; Kidney Failure, Chronic - therapy; Male; Membrane proteins; Middle Aged; P-Selectin - blood; P10; Parathyroid; Parathyroid hormone; Patients; Phosphorus; Platelets; prediction; Renal Dialysis - statistics & numerical data; ROC Curve; Thromboplastin; Thrombospondin; Thrombospondins - blood; Treatment Outcome; Urea
• ISSN: 0887-8013; 1098-2825
• DOI: 10.1002/jcla.22662

Background CD62P is a platelet α‐granule membrane protein, and P10 is a platelet membrane glycoprotein thrombospondin. To better understand the effects of hemodialysis (HD), we have conducted this study to investigate CD62P and P10 in assessing the efficacy of HD in treating patients with end‐stage renal disease (ESRD). Methods The case group consisted of 111 patients suffering ESRD treated with regular HD and the control group enrolled 117 healthy subjects. Before and after HD treatment, a series of parameters were observed, based on which, CD62P and P10 levels were detected in the patients in two groups before and after HD therapy. The correlation analysis analyzed the correlations of CD62P and P10 markers with serum creatinine (Scr), blood urea nitrogen (BUN), and subjective score; and logistic regression analysis was performed to reveal factors affecting the efficacy of HD. Results BUN, Scr, serum phosphorus, intact parathyroid hormone (iPTH), fibrinogen, and β2‐microglobulin (β2‐MG) decreased while hemoglobin, albumin, and activated partial thromboplastin time increased in the patients suffering ESRD; patients presented with improvements in subjective symptoms and an increase in dry weight. CD62P and P10 levels were lower in post‐treatment patients. CD62P and P10 positively correlated with Scr, BUN and subjective score; post‐treatment CD62P and P10 levels, BUN, hemoglobin, albumin, triglyceride, iPTH, β2‐MG, and fibrinogen were correlated with the efficacy of HD. Conclusion CD62P and P10 might be correlated to the efficacy of HD in treating ESRD, in turn providing predictive markers for assessing the ability of HD in treating ESRD.