Successful Management of Adolescent Bupropion Overdose with Intravenous Lipid Emulsion Therapy

Abstract Bupropion overdose in the pediatric setting poses significant potential for toxicity. We present the case of a 15-year-old female patient presenting with intentional bupropion overdose resulting in generalized tonic–clonic seizures, severe acidosis, vomiting, and tachycardia after ingestion...

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Bibliographic Details
Published in:Journal of pediatric intensive care 2019-12, Vol.8 (4), p.242-246
Main Authors: Bornstein, Kasha, Montrief, Tim, Anwar Parris, Mehruba
Format: Article
Language:English
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Case Report
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Summary:Abstract Bupropion overdose in the pediatric setting poses significant potential for toxicity. We present the case of a 15-year-old female patient presenting with intentional bupropion overdose resulting in generalized tonic–clonic seizures, severe acidosis, vomiting, and tachycardia after ingestion of between 1,650 to 9,000 mg (24–133 mg/kg) of bupropion. The patient was admitted to pediatric intensive care unit (PICU) where toxicity was resolved promptly following administration of intravenous lipid emulsion (ILE) infusion. ILE is a first-line treatment for other forms of toxicity including unintended local anesthetic administration. ILE use is not a first-line treatment in this setting, but this case presents a positive subsequent patient outcome.
ISSN:2146-4618
2146-4626
DOI:10.1055/s-0039-1693483