Gene expression profile analysis of ileum transcriptomes in pigs fed Gelsemium elegans plants

Gelsemium elegans is a flowering plant in the Loganiaceae. Because it can promote the growth of pigs and sheep, it is widely used, including in veterinary clinics, but little information is available about its biological effects. Here, we used high-throughput sequencing to characterize the different...

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Bibliographic Details
Published in:Scientific reports 2019-10, Vol.9 (1), p.15756-8, Article 15756
Main Authors: Huang, Chong-Yin, Yang, Kun, Cao, Jun-Jie, Li, Yu-Juan, Wang, Zi-Yuan, Yu, Hui, Sun, Zhi-Liang, Zheng, Xiaofeng, Liu, Zhao-Ying
Format: Article
Language:English
Subjects:
38
38/91
631/1647/514
631/337/2019
Animal Feed
Animals
Anti-inflammatory agents
Anti-Inflammatory Agents - pharmacology
Biological effects
Cytokines - immunology
Flowering
Flowering plants
Gelsemium
Gelsemium elegans
Gene expression
Gene Expression Regulation - immunology
Humanities and Social Sciences
Ileum
Ileum - immunology
Immune response
Inflammation
Interleukin 1
multidisciplinary
Next-generation sequencing
Science
Science (multidisciplinary)
Swine
Therapeutic applications
Transcriptome - immunology
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Summary:Gelsemium elegans is a flowering plant in the Loganiaceae. Because it can promote the growth of pigs and sheep, it is widely used, including in veterinary clinics, but little information is available about its biological effects. Here, we used high-throughput sequencing to characterize the differentially expressed genes (DEGs) in the ileums of pigs between a control group and a group fed Gelsemium elegans for 45 days. We found that Gelsemium elegans affected many inflammatory and immune pathways, including biological processes such as defense responses, inflammation and immune responses. Moreover, this study identified several important genes related to the anti-inflammatory activity of Gelsemium elegans (e.g., CXCL-8, IL1A, and CSF2), which will be beneficial for further study of the pharmacological mechanisms and clinical applications of Gelsemium elegans .
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-019-52374-4