Impact of Vitamin D Status in Chronic Liver Disease

• Published in: Journal of clinical and experimental hepatology 2019-09, Vol.9 (5), p.574-580
• Main Authors: Khan, Mushtaq A., Dar, Hilal A., Baba, Muneer A., Shah, Altaf H., Singh, Bhagat, Shiekh, Nadeem A.
• Format: Article
• Language: English
• Subjects: Child-Pugh score; MELD score; Original; portal hypertension; vitamin D
• ISSN: 0973-6883; 2213-3453
• DOI: 10.1016/j.jceh.2019.03.001

Vitamin D deficiency is extremely common in chronic liver disease (CLD) patients. Up to 93% of these patients have some degree of vitamin D insufficiency. Liver plays an important role in the metabolism and pleiotropic functions of vitamin D. Vitamin D deficiency has been associated with increased mortality, bacterial infections, portal hypertension complications, and fibrosis severity. We aimed to determine the impact of vitamin D level in CLD. One hundred fifty individuals consisting of 75 cirrhotic patients (cases) and 75 respective attendants (controls) were enrolled between July 2015 and July 2017. A detailed clinical and laboratory evaluation was done along with estimation of vitamin D level. Unpaired t-test and analysis of variance was used to compare difference in the level of continuous variables between different groups. Linear regression analysis was performed to analyze the correlation between vitamin D deficiency and severity of liver disease. The age of patients ranged from 18 years to 69 years with mean of 48.85 ± 13.6 years in the case group and 46.57 ± 17.24 years in the control group. Out of 75 CLD patients, vitamin D deficiency (