Molecular Characterization of Leishmania RNA virus 2 in Leishmania major from Uzbekistan

Here we report sequence and phylogenetic analysis of two new isolates of (LRV2) found in isolated from human patients with cutaneous leishmaniasis in south Uzbekistan. These new virus-infected flagellates were isolated in the same region of Uzbekistan and the viral sequences differed by only ninetee...

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Bibliographic Details
Published in:Genes 2019-10, Vol.10 (10), p.830
Main Authors: Kleschenko, Yuliya, Grybchuk, Danyil, Matveeva, Nadezhda S, Macedo, Diego H, Ponirovsky, Evgeny N, Lukashev, Alexander N, Yurchenko, Vyacheslav
Format: Article
Language:English
Subjects:
Cutaneous leishmaniasis
Flagellates
Genome, Viral
Leishmania
Leishmania major
Leishmania major - virology
Leishmania RNA virus 2
Leishmaniavirus - classification
Leishmaniavirus - genetics
Leishmaniavirus - pathogenicity
Mutation
Nucleotide sequence
Parasites
Parasitic diseases
patients
Phylogenetics
Phylogeny
Polymorphism, Single Nucleotide
provenance
RNA polymerase
RNA viruses
single nucleotide polymorphism
Turkmenistan
Uzbekistan
Viral infections
Viruses
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Summary:Here we report sequence and phylogenetic analysis of two new isolates of (LRV2) found in isolated from human patients with cutaneous leishmaniasis in south Uzbekistan. These new virus-infected flagellates were isolated in the same region of Uzbekistan and the viral sequences differed by only nineteen SNPs, all except one being silent mutations. Therefore, we concluded that they belong to a single LRV2 species. New viruses are closely related to the LRV2-Lmj-ASKH documented in Turkmenistan in 1995, which is congruent with their shared host ( . ) and common geographical origin.
ISSN:2073-4425
2073-4425
DOI:10.3390/genes10100830