Therapeutic effects of methylphenidate for attention-deficit/hyperactivity disorder in children with borderline intellectual functioning or intellectual disability: A systematic review and meta-analysis

Attention-deficit/hyperactivity disorder (ADHD) frequently co-occurs with intellectual disability in children, and may further compromise learning. Methylphenidate is a first-line treatment for ADHD, however no previous meta-analysis has evaluated its overall efficacy for ADHD in children with comor...

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Bibliographic Details
Published in:Scientific reports 2019-11, Vol.9 (1), p.15908-10, Article 15908
Main Authors: Sun, Cheuk-Kwan, Tseng, Ping-Tao, Wu, Ching-Kuan, Li, Dian-Jeng, Chen, Tien-Yu, Stubbs, Brendon, Carvalho, Andre F, Chen, Yen-Wen, Lin, Pao-Yen, Cheng, Yu-Shian, Wu, Ming-Kung
Format: Article
Language:English
Subjects:
631/378/2649/1579
692/617/375/366/1311
Attention Deficit Disorder with Hyperactivity - complications
Attention Deficit Disorder with Hyperactivity - drug therapy
Attention Deficit Disorder with Hyperactivity - pathology
Attention deficit hyperactivity disorder
Central Nervous System Stimulants - adverse effects
Central Nervous System Stimulants - therapeutic use
Child
Children
Cognitive ability
Humanities and Social Sciences
Humans
Hyperactivity
Intellectual disabilities
Intellectual Disability - complications
Intellectual Disability - pathology
Intelligence
Meta-analysis
Methylphenidate
Methylphenidate - adverse effects
Methylphenidate - therapeutic use
multidisciplinary
Odds Ratio
Placebo Effect
Science
Science (multidisciplinary)
Severity of Illness Index
Systematic review
Treatment Outcome
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Summary:Attention-deficit/hyperactivity disorder (ADHD) frequently co-occurs with intellectual disability in children, and may further compromise learning. Methylphenidate is a first-line treatment for ADHD, however no previous meta-analysis has evaluated its overall efficacy for ADHD in children with comorbid intellectual disability (ID) or borderline intellectual functioning. The PubMed/MEDLINE, Cochrane CENTRAL and ScienceDirect databases were systematically searched from inception through 2018/7/15 for clinical studies that investigated the effects of methylphenidate in children with ADHD and ID. A random-effects model meta-analysis was used for data synthesis. Eight studies (average Jadad score = 2.5) enrolling 242 participants receiving methylphenidate and 181 participants receiving placebo were included. The meta-analysis showed that methylphenidate led to a significant improvement in ADHD symptoms relative to placebo (Hedges’ g  = 0.878, p  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-019-52205-6