The effect of ifosfamide, epirubicin, and recombinant human endostatin therapy on a cardiac angiosarcoma: A case report

• Published in: Medicine (Baltimore) 2019-04, Vol.98 (17), p.e15290-e15290
• Main Authors: Jiang, Lijun, Xu, Xingjie, Davies, Henry, Shi, Kexin
• Format: Article
• Language: English
• Subjects: Antineoplastic Agents - therapeutic use; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Clinical Case Report; Endostatins - therapeutic use; Epirubicin - therapeutic use; Heart Neoplasms - drug therapy; Heart Neoplasms - pathology; Heart Neoplasms - surgery; Hemangiosarcoma - drug therapy; Hemangiosarcoma - pathology; Hemangiosarcoma - surgery; Humans; Ifosfamide - therapeutic use; Liver Neoplasms - drug therapy; Liver Neoplasms - secondary; Lung Neoplasms - drug therapy; Lung Neoplasms - secondary; Male; Middle Aged; Positron Emission Tomography Computed Tomography; Recombinant Proteins
• ISSN: 0025-7974; 1536-5964
• DOI: 10.1097/MD.0000000000015290

Cardiac angiosarcoma is a rare malignant tumor, for which only surgery has been proven to be effective to date. Currently there are no reports as to whether a postoperative regimen of ifosfamide, epirubicin, and recombinant human endostatin is effective. The patient presented to us with chest pain and dyspnea. Enhanced computerized tomography (CT) and positron emission tomography-computerized tomography (PET-CT) suggested pericarditis and an atrial perforation, but malignancy was suspected, so the patient underwent an operation to resect the tumor and repair. Pathology of the tumor reseccted at operation showed the tumor to be an angiosarcoma. After the surgery, the patient was stared on a paclitaxel chemotherapy regimen (135 mg/m once every 3 weeks). However, 2 cycles later, pulmonary and hepatic metastases were found. Chemotherapy was then changed to ifosfamide, epirubicin (ifosfamide 2000 mg/m days 1-3, epirubicin 70 mg/m days 1-2) and recombinant human endostatin (7.5 mg/m days 1-14) in 3 weekly cycles. Three cycles later, follow-up showed that chemotherapy had delayed progression of the pulmonary metastases, but that the hepatic node was still growing. The patient has now survived 8 months post surgery and is still on follow-up. This case shows us that operation on late stage cardiac angiosarcomas can alleviate a patient's symptoms; postoperative paclitaxel monotherapy was insufficient and ifosfamide and epirubicin plus recombinant human endostatin has a limited effect on late stage cardiac angiosarcoma. Studies with a larger sample size are needed for verification of these findings.