Renal lesions in leptin receptor-deficient medaka (Oryzias latipes)

The aim of this study was to elucidate the renal lesions of leptin receptor-deficient medaka showing hyperglycemia and hypoinsulinemia and to evaluate the usefulness of the medaka as a model of diabetic nephropathy. Leptin receptor-deficient medaka at 20 and 30 weeks of age showed hyperglycemia and...

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Bibliographic Details
Published in:Journal of Toxicologic Pathology 2019, Vol.32(4), pp.297-303
Main Authors: Chisada, Shinichi, Sugiyama, Akihiko
Format: Article
Language:English
Subjects:
Age
Animal models
Arterioles
Atrophy
Cell proliferation
Creatinine
Diabetes
Diabetes mellitus
Diabetic nephropathy
Dilation
Enlargement
Fibrin
Glucose
Hyperglycemia
Kidneys
leptin receptor-deficient medaka
Lesions
Nephropathy
Sensory neurons
Short Communication
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Summary:The aim of this study was to elucidate the renal lesions of leptin receptor-deficient medaka showing hyperglycemia and hypoinsulinemia and to evaluate the usefulness of the medaka as a model of diabetic nephropathy. Leptin receptor-deficient medaka at 20 and 30 weeks of age showed hyperglycemia and hypoinsulinemia; they also showed a higher level of plasma creatinine than the control medaka. Histopathologically, dilation of glomerular capillary lumina and of afferent/efferent arterioles was observed in leptin receptor-deficient medaka at 20 weeks of age, and then glomerular enlargement with cell proliferation and matrix expansion, formation of fibrin cap-like lesions, glomerular atrophy with Bowman’s capsule dilation, and renal tubule dilation were observed at 30 weeks of age. These histopathological characteristics of leptin receptor-deficient medaka were similar to the characteristics of kidney lesions of human and rodent models of type II diabetes mellitus, making leptin receptor-deficient medaka a useful model of diabetic nephropathy.
ISSN:0914-9198
1881-915X
1347-7404
DOI:10.1293/tox.2019-0021