The Overlooked Immune State in Candidemia: A Risk Factor for Mortality

Lymphopenia has been related to increased mortality in septic patients. Nonetheless, the impact of lymphocyte count on candidemia mortality and prognosis has not been addressed. We conducted a retrospective study, including all admitted patients with candidemia from 2007 to 2016. We examined lymphoc...

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Published in:Journal of clinical medicine 2019-09, Vol.8 (10), p.1512
Main Authors: Ortega-Loubon, Christian, Cano-Hernández, Beatriz, Poves-Alvarez, Rodrigo, Muñoz-Moreno, María Fe, Román-García, Patricia, Balbás-Alvarez, Sara, de la Varga-Martínez, Olga, Gómez-Sánchez, Esther, Gómez-Pesquera, Estefanía, Lorenzo-López, Mario, Tamayo, Eduardo, Heredia-Rodríguez, María
Format: Article
Language:English
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Summary:Lymphopenia has been related to increased mortality in septic patients. Nonetheless, the impact of lymphocyte count on candidemia mortality and prognosis has not been addressed. We conducted a retrospective study, including all admitted patients with candidemia from 2007 to 2016. We examined lymphocyte counts during the first 5 days following the diagnosis of candidemia. Multivariable logistic regression analysis was performed to determine the relationship between lymphocyte count and mortality. Classification and Regression Tree analysis was used to identify the best cut-off of lymphocyte count for mortality associated with candidemia. From 296 cases of candidemia, 115 died, (39.8% 30-day mortality). Low lymphocyte count was related to mortality and poor outcome (p < 0.001). Lymphocyte counts
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm8101512