A case of Warthin-like papillary thyroid carcinoma with diffuse sclerosing stroma and a novel RET mutation: a new entity or a combined tumour?

Activating mutations of the gene have been described for both papillary (chromosomal rearrangement) and medullary (missense mutations) thyroid carcinomas. Here, we describe a case of a Warthin-like variant of papillary thyroid carcinoma displaying some morphological aspects that mimic the diffuse sc...

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Bibliographic Details
Published in:Ecancermedicalscience 2019-10, Vol.13, p.965
Main Authors: Maffini, Fausto, Lorenzini, Daniele, Lepanto, Daniela, De Fiori, Elvio, Fumagalli, Caterina, Rappa, Alessandra, Tagliabue, Marta, Barberis, Massimo
Format: Article
Language:English
Subjects:
Case Report
Deoxyribonucleic acid
DNA
Kinases
Medical prognosis
Mortality
Mutation
Thyroid cancer
Tumors
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Summary:Activating mutations of the gene have been described for both papillary (chromosomal rearrangement) and medullary (missense mutations) thyroid carcinomas. Here, we describe a case of a Warthin-like variant of papillary thyroid carcinoma displaying some morphological aspects that mimic the diffuse sclerosing variant. The tumour harboured V600E mutation and a novel germline point mutation in the gene, with unknown clinical and pathological meaning.
ISSN:1754-6605
1754-6605
DOI:10.3332/ecancer.2019.965