Narrative impairment, white matter damage and CSF biomarkers in the Alzheimer's disease spectrum

Narrative discourse (ND) refers to one's ability to verbally reproduce a sequence of temporally and logically-linked events. Impairments in ND may occur in subjects with Amnestic Mild Cognitive Impairment (aMCI) and Alzheimer's Disease (AD), but correlates across this function, neuroimagin...

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Published in:Aging (Albany, NY.) NY.), 2019-10, Vol.11 (20), p.9188-9208
Main Authors: Drummond, Claudia, Coutinho, Gabriel, Monteiro, Marina Carneiro, Assuncao, Naima, Teldeschi, Alina, de Souza, Andrea Silveira, Oliveira, Natalia, Bramati, Ivanei, Sudo, Felipe Kenji, Vanderboght, Bart, Brandao, Carlos Otavio, Fonseca, Rochele Paz, de Oliveira-Souza, Ricardo, Moll, Jorge, Mattos, Paulo, Tovar-Moll, Fernanda
Format: Article
Language:English
Subjects:
Aged
Alzheimer Disease
Biomarkers - cerebrospinal fluid
Cognitive Dysfunction
Female
Humans
Male
Neuropsychological Tests
Research Paper
White Matter - pathology
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Summary:Narrative discourse (ND) refers to one's ability to verbally reproduce a sequence of temporally and logically-linked events. Impairments in ND may occur in subjects with Amnestic Mild Cognitive Impairment (aMCI) and Alzheimer's Disease (AD), but correlates across this function, neuroimaging and cerebrospinal fluid (CSF) AD biomarkers remain understudied. We sought to measure correlates among ND, Diffusion Tensor Imaging (DTI) indexes and AD CSF biomarkers in patients within the AD spectrum. Groups differed in narrative production (NProd) and comprehension. aMCI and AD presented poorer inference abilities than controls. AD subjects were more impaired than controls and aMCI regarding WB (p
ISSN:1945-4589
1945-4589
DOI:10.18632/aging.102391