Transcriptomic Analysis of mRNA-lncRNA-miRNA Interactions in Hepatocellular Carcinoma

Fully elucidating the molecular mechanisms of non-coding RNAs (ncRNAs), including micro RNAs (miRNAs) and long non-coding RNAs (lncRNAs), underlying hepatocarcinogenesis is challenging. We characterized the expression profiles of ncRNAs and constructed a regulatory mRNA-lncRNA-miRNA (MLMI) network b...

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Bibliographic Details
Published in:Scientific reports 2019-11, Vol.9 (1), p.16096-12, Article 16096
Main Authors: Tang, Xia, Feng, Delong, Li, Min, Zhou, Jinxue, Li, Xiaoyuan, Zhao, Dachun, Hao, Bingtao, Li, Dewei, Ding, Keyue
Format: Article
Language:English
Subjects:
38/39
38/91
631/67/68/2486
692/4020/4021/1607/1610/4029
Carcinogenesis
Carcinoma, Hepatocellular - genetics
Carcinoma, Hepatocellular - metabolism
Computational Biology
Gene expression
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Hepatocellular carcinoma
Humanities and Social Sciences
Humans
Liver cancer
Liver Neoplasms - genetics
Liver Neoplasms - metabolism
MAP kinase
MicroRNAs - genetics
MicroRNAs - metabolism
miRNA
Molecular modelling
multidisciplinary
p53 Protein
RNA, Long Noncoding - genetics
RNA, Long Noncoding - metabolism
RNA, Messenger - genetics
RNA, Messenger - metabolism
Science
Science (multidisciplinary)
Transcriptome
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Summary:Fully elucidating the molecular mechanisms of non-coding RNAs (ncRNAs), including micro RNAs (miRNAs) and long non-coding RNAs (lncRNAs), underlying hepatocarcinogenesis is challenging. We characterized the expression profiles of ncRNAs and constructed a regulatory mRNA-lncRNA-miRNA (MLMI) network based on transcriptome sequencing (RNA-seq) of hepatocellular carcinoma (HCC, n  = 9) patients. Of the identified miRNAs ( n  = 203) and lncRNAs ( n  = 1,090), we found 16 significantly differentially expressed (DE) miRNAs and three DE lncRNAs. The DE RNAs were highly enriched in 21 functional pathways implicated in HCC ( p  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-019-52559-x