Paraoxonase responses to exercise and niacin therapy in men with metabolic syndrome

Our purpose was to characterize changes in paraoxonase 1 (PON1) activity and concentration after single aerobic exercise sessions conducted before and after 6 weeks of niacin therapy in men with metabolic syndrome (MetS). Twelve men with MetS expended 500 kcal by walking at 65% of VO 2max before and...

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Published in:Redox report : communications in free radical research 2015-01, Vol.20 (1), p.42-48
Main Authors: Taylor, James Kyle, Plaisance, Eric P., Mahurin, A. Jack, Mestek, Michael L., Moncada-Jimenez, Jose, Grandjean, Peter W.
Format: Article
Language:English
Subjects:
Adult
Apolipoprotein A-I - blood
Aryldialkylphosphatase - blood
Exercise
Exercise Therapy
Humans
Lipid oxidation
Lipids - chemistry
Lipoprotein particle size
Lipoproteins, HDL - blood
Male
Metabolic Syndrome - blood
Metabolic Syndrome - enzymology
Middle Aged
Niacin
Niacin - therapeutic use
Obesity - complications
Oxygen - chemistry
Paraoxonase
Peroxidase - blood
Vasodilator Agents - chemistry
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Summary:Our purpose was to characterize changes in paraoxonase 1 (PON1) activity and concentration after single aerobic exercise sessions conducted before and after 6 weeks of niacin therapy in men with metabolic syndrome (MetS). Twelve men with MetS expended 500 kcal by walking at 65% of VO 2max before and after a 6-week regimen of niacin. Niacin doses were titrated by 500 mg/week from 500 to 1500 mg/day and maintained at 1500 mg/day for the last 4 weeks. Fasting blood samples were collected before and 24 hours after each exercise session and analyzed for PON1 activity, PON1 concentration, myeloperoxidase (MPO), apolipoprotein A1, oxidized low-density lipoprotein (oLDL), lipoprotein particle sizes and concentrations. PON1 activity, PON1 concentration, MPO, and oLDL were unaltered following the independent effects of exercise and niacin (P > 0.05 for all). High-density lipoprotein particle size decreased by 3% (P = 0.040) and concentrations of small very low-density lipoprotein increased (P = 0.016) following exercise. PON1 activity increased 6.1% (P = 0.037) and PON1 concentrations increased 11.3% (P = 0.015) with the combination of exercise and niacin. Exercise and niacin works synergistically to increase PON1 activity and concentration with little or no changes in lipoproteins or markers of lipid oxidation.
ISSN:1351-0002
1743-2928
DOI:10.1179/1351000214Y.0000000103