Paraoxonase responses to exercise and niacin therapy in men with metabolic syndrome

• Published in: Redox report : communications in free radical research 2015-01, Vol.20 (1), p.42-48
• Main Authors: Taylor, James Kyle, Plaisance, Eric P., Mahurin, A. Jack, Mestek, Michael L., Moncada-Jimenez, Jose, Grandjean, Peter W.
• Format: Article
• Language: English
• Subjects: Adult; Apolipoprotein A-I - blood; Aryldialkylphosphatase - blood; Exercise; Exercise Therapy; Humans; Lipid oxidation; Lipids - chemistry; Lipoprotein particle size; Lipoproteins, HDL - blood; Male; Metabolic Syndrome - blood; Metabolic Syndrome - enzymology; Middle Aged; Niacin; Niacin - therapeutic use; Obesity - complications; Oxygen - chemistry; Paraoxonase; Peroxidase - blood; Vasodilator Agents - chemistry
• ISSN: 1351-0002; 1743-2928
• DOI: 10.1179/1351000214Y.0000000103

Our purpose was to characterize changes in paraoxonase 1 (PON1) activity and concentration after single aerobic exercise sessions conducted before and after 6 weeks of niacin therapy in men with metabolic syndrome (MetS). Twelve men with MetS expended 500 kcal by walking at 65% of VO 2max before and after a 6-week regimen of niacin. Niacin doses were titrated by 500 mg/week from 500 to 1500 mg/day and maintained at 1500 mg/day for the last 4 weeks. Fasting blood samples were collected before and 24 hours after each exercise session and analyzed for PON1 activity, PON1 concentration, myeloperoxidase (MPO), apolipoprotein A1, oxidized low-density lipoprotein (oLDL), lipoprotein particle sizes and concentrations. PON1 activity, PON1 concentration, MPO, and oLDL were unaltered following the independent effects of exercise and niacin (P > 0.05 for all). High-density lipoprotein particle size decreased by 3% (P = 0.040) and concentrations of small very low-density lipoprotein increased (P = 0.016) following exercise. PON1 activity increased 6.1% (P = 0.037) and PON1 concentrations increased 11.3% (P = 0.015) with the combination of exercise and niacin. Exercise and niacin works synergistically to increase PON1 activity and concentration with little or no changes in lipoproteins or markers of lipid oxidation.