Pro-oxidant versus anti-oxidant effects of seeds aglycone extracts of Lepidium sativum and Eruca vesicaria Linn., in vitro, and on neutrophil nitro-oxidative functions

This study evaluated the anti-inflammatory and antioxidant properties of seeds aglycone extracts from Lepidium sativum (LS) and Eruca vesicaria (EV) Linn ., on oxidative damages in vitro and on neutrophil nitro-oxidative functions. The results showed that LS and EV aglycone extracts attenuated liver...

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Bibliographic Details
Published in:Journal of food science and technology 2019-12, Vol.56 (12), p.5492-5499
Main Authors: Tounsi, Nabila, Djerdjouri, Bahia, Yahia, Ouahiba Ait, Belkebir, Aicha
Format: Article
Language:English
Subjects:
Antioxidants
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Eruca vesicaria
Exocytosis
Food Science
Glutathione
Health promotion
Inflammation
Lepidium sativum
Leukocytes (neutrophilic)
Lipids
Microorganisms
Neutrophils
Nitric oxide
Nutrition
Original
Original Article
Oxidation
Oxidative stress
Oxidizing agents
Peritoneum
Peroxidase
Scavenging
Seeds
Superoxide
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Summary:This study evaluated the anti-inflammatory and antioxidant properties of seeds aglycone extracts from Lepidium sativum (LS) and Eruca vesicaria (EV) Linn ., on oxidative damages in vitro and on neutrophil nitro-oxidative functions. The results showed that LS and EV aglycone extracts attenuated liver microsomal lipids and proteins oxidation through a potent antioxidant effect as attested by the dose dependent quenching of DPPH radical scavenging activity. LS and EV aglycone extracts inhibited dose dependently the production of superoxide anion by BALB/c mice-derived peritoneal neutrophils, whereas they slightly enhanced exocytosis of myeloperoxidase (MPO), a marker of azurophilic granules. Interestingly, only LS replenished glutathione (GSH) and nitric oxide levels, indicating a fine differential effect. This study highlighted the subtle oxidative and antioxidant capacity of LS and EV seeds aglycone extracts. These health promoting compounds could be used to finely modulate critical events involved in microbial infection, inflammation and nitro-oxidative stress.
ISSN:0022-1155
0975-8402
DOI:10.1007/s13197-019-04021-z