A structural connectivity convergence zone in the ventral and anterior temporal lobes: Data-driven evidence from structural imaging

The hub-and-spoke model of semantic cognition seeks to reconcile embodied views of a fully distributed semantic network with patient evidence, primarily from semantic dementia, who demonstrate modality-independent conceptual deficits associated with atrophy centred on the ventrolateral anterior temp...

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Bibliographic Details
Published in:Cortex 2019-11, Vol.120, p.298-307
Main Authors: Bajada, Claude J., Trujillo-Barreto, Nelson J., Parker, Geoff J.M., Cloutman, Lauren L., Lambon Ralph, Matthew A.
Format: Article
Language:English
Subjects:
Adult
Anterior temporal lobe
Brain Mapping
Connectivity
Diffusion Magnetic Resonance Imaging
Female
Humans
Laplacian eigenmapping
Male
Middle Aged
Nerve Net - diagnostic imaging
Semantics
Spectral reordering
Temporal Lobe - diagnostic imaging
Young Adult
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Summary:The hub-and-spoke model of semantic cognition seeks to reconcile embodied views of a fully distributed semantic network with patient evidence, primarily from semantic dementia, who demonstrate modality-independent conceptual deficits associated with atrophy centred on the ventrolateral anterior temporal lobe. The proponents of this model have recently suggested that the temporal cortex is a graded representational space where concepts become less linked to a specific modality as they are processed farther away from primary and secondary sensory cortices and towards the ventral anterior temporal lobe. To explore whether there is evidence that the connectivity patterns of the temporal lobe converge in its ventral anterior end the current study uses three dimensional Laplacian eigenmapping, a technique that allows visualisation of similarity in a low dimensional space. In this space similarity is encoded in terms of distances between data points. We found that the ventral and anterior temporal lobe is in a unique position of being at the centre of mass of the data points within the connective similarity space. This can be interpreted as the area where the connectivity profiles of all other temporal cortex voxels converge. This study is the first to explicitly investigate the pattern of connectivity and thus provides the missing link in the evidence that the ventral anterior temporal lobe can be considered a multi-modal graded hub.
ISSN:0010-9452
1973-8102
DOI:10.1016/j.cortex.2019.06.014