Aortic stiffness, pressure and flow pulsatility, and target organ damage

Measures of aortic stiffness and pressure and flow pulsatility have emerged as correlates of and potential contributors to cardiovascular disease, dementia, and kidney disease. Higher aortic stiffness and greater pressure and flow pulsatility are associated with excessive pulsatile load on the heart...

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Bibliographic Details
Published in:Journal of applied physiology (1985) 2018-12, Vol.125 (6), p.1871-1880
Main Author: Mitchell, Gary F
Format: Article
Language:English
Subjects:
Animals
Aorta - physiology
Brain - physiology
Disease - etiology
Humans
Hypertension - physiopathology
Kidney - physiology
Microvessels - physiology
Pulsatile Flow
Review
Sex Characteristics
Vascular Stiffness
Ventricular Function, Left
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Summary:Measures of aortic stiffness and pressure and flow pulsatility have emerged as correlates of and potential contributors to cardiovascular disease, dementia, and kidney disease. Higher aortic stiffness and greater pressure and flow pulsatility are associated with excessive pulsatile load on the heart, which increases mass and reduces global longitudinal strain of the left ventricle. Excessive stiffness and pulsatility are also associated with microvascular lesions in high-flow organs, such as the brain and kidney, suggesting that small vessels in these organs are damaged by pulsatility. This brief review will summarize evidence relating aortic stiffness to cardiovascular, brain, and kidney disease.
ISSN:8750-7587
1522-1601
DOI:10.1152/japplphysiol.00108.2018